SYNTHESIS AND PHOTOCHEMIOTHERAPEUTIC ACTIVITY OF THIOPYRANO[2,3-E]INDOL-2-ONES
- Autori: BARRAJA P; SCIABICA L; DIANA P; LAURIA A; MONTALBANO A; ALMERICO AM; DATTOLO G; CIRRINCIONE G; DISARO S; BASSO G; VIOLA G; DALL'ACQUA F
- Anno di pubblicazione: 2005
- Tipologia: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/21203
Abstract
A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining new photochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferative effect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range.