2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity and mechanism of action
- Authors: Raffa, D; Maggio, B; Plescia, F; Cascioferro, S; Raimondi, MV; Cusimano, MG; Schillaci, D; Daidone, G; Amico, G; Carollo, C; Conaldi P
- Publication year: 2013
- Type: Proceedings
- OA Link: http://hdl.handle.net/10447/79425
Abstract
Several new 2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides were synthesized by stirring in pyridine the opportune acid chlorides with the appropriate anthranilamide derivatives. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).