Synthesis and antiproliferative activity of a natural like glucosyl polycyclic compound
- Authors: Maggio, B; Raimondi, MV; Cascioferro, S; Scherrmann, MC; Prosa, N; Lauricella, M; Carlisi, D; Daidone, G
- Publication year: 2014
- Type: Proceedings
- OA Link: http://hdl.handle.net/10447/98587
Abstract
A new polycylic compound was synthesized and evaluated for its antiproliferative activity against the NCI panel of human tumoral cell lines showing IC50 values in the range 0.47-5.43 µM. The compound induced a decrease of the level of cyclin B1, whereas increased the level of the inhibitor p21 WAF1