| 2024 |
Exploring the therapeutic potential of focal adhesion kinase inhibition in overcoming chemoresistance in pancreatic ductal adenocarcinoma |
Review essay (rassegna critica) |
Vai |
| 2024 |
Novel [1,3,4]Thiadiazole[3,2-a]pyrimidin-5-ones as Promising Biofilm Dispersal Agents against Relevant Gram-Positive and Gram-Negative Pathogens |
Articolo in rivista |
Vai |
| 2024 |
Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: synthesis, mechanistic insights and promising antitumor and safety profile |
Articolo in rivista |
Vai |
| 2024 |
Triazole derivatives inhibit the VOR complex-mediated nuclear transport of extracellular particles: Potential application in cancer and HIV-1 infection |
Articolo in rivista |
Vai |
| 2023 |
Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What is New? |
Articolo in rivista |
Vai |
| 2023 |
1,2,4-Amino-triazine derivatives as pyruvate dehydrogenase kinase inhibitors: Synthesis and pharmacological evaluation |
Articolo in rivista |
Vai |
| 2023 |
Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma |
Articolo in rivista |
Vai |
| 2023 |
Development of a new indole derivative dry powder for inhalation for the treatment of biofilm-associated lung infections |
Articolo in rivista |
Vai |
| 2023 |
1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1 |
Articolo in rivista |
Vai |
| 2023 |
Discovery of the 3-Amino-1,2,4-triazine-Based Library as Selective PDK1 Inhibitors with Therapeutic Potential in Highly Aggressive Pancreatic Ductal Adenocarcinoma |
Articolo in rivista |
Vai |
| 2023 |
Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy |
Articolo in rivista |
Vai |
| 2023 |
Nortopsentins as Leads from Marine Organisms for Anticancer and Anti-Inflammatory Agent Development |
Review essay (rassegna critica) |
Vai |
| 2023 |
A Combination of Polymethoxyflavones from Citrus sinensis and Prenylflavonoids from Humulus lupulus Counteracts IL-1β-Induced Differentiated Caco-2 Cells Dysfunction via a Modulation of NF-κB/Nrf2 Activation |
Articolo in rivista |
Vai |
| 2022 |
Eight-membered heterocycles with two heteroatoms in a 1,3-relationship of interest in medicinal chemistry |
Capitolo o Saggio |
Vai |
| 2022 |
A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells |
Articolo in rivista |
Vai |
| 2022 |
Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification |
Articolo in rivista |
Vai |
| 2022 |
Eight-Membered Rings With Two Heteroatoms 1,2 |
Capitolo o Saggio |
Vai |
| 2022 |
Eight-Membered Rings With Two Heteroatoms 1,5 |
Capitolo o Saggio |
Vai |
| 2022 |
Eight-Membered Rings With Two Heteroatoms 1,3 |
Capitolo o Saggio |
Vai |
| 2022 |
Biofilm Formation as Valuable Target to Fight against Severe Chronic Infections |
Articolo in rivista |
Vai |
| 2021 |
Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation |
Articolo in rivista |
Vai |
| 2021 |
CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin |
Articolo in rivista |
Vai |
| 2021 |
Therapeutic strategies to counteract antibiotic resistance in MRSA biofilm-associated infections |
Review essay (rassegna critica) |
Vai |
| 2021 |
Dynamic-shared pharmacophore approach as tool to design new allosteric PRC2 inhibitors, targeting EED binding pocket |
Articolo in rivista |
Vai |
| 2021 |
1,2,4-Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase |
Articolo in rivista |
Vai |
| 2021 |
1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A |
Articolo in rivista |
Vai |
| 2021 |
Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy |
Articolo in rivista |
Vai |
| 2021 |
Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides |
Articolo in rivista |
Vai |
| 2021 |
SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance |
Articolo in rivista |
Vai |
| 2021 |
Novel strategies in the war against antibiotic resistance |
Articolo in rivista |
Vai |
| 2021 |
Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum |
Articolo in rivista |
Vai |
| 2021 |
Eight-membered heterocycles with two heteroatoms in a 1,2-relationship of interest in medicinal chemistry |
Capitolo o Saggio |
Vai |
| 2020 |
3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1HIndole derivatives as new anticancer agents in the treatment of pancreatic ductal adenocarcinoma |
Articolo in rivista |
Vai |
| 2020 |
Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance |
Articolo in rivista |
Vai |
| 2020 |
Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells |
Articolo in rivista |
Vai |
| 2020 |
Citrus sinensis and Vitis vinifera Protect Cardiomyocytes from Doxorubicin-Induced Oxidative Stress: Evaluation of Onconutraceutical Potential of Vegetable Smoothies |
Articolo in rivista |
Vai |
| 2020 |
Inhibitors of antibiotic resistance mechanisms: clinical applications and future perspectives |
Articolo in rivista |
Vai |
| 2020 |
New Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives Inhibit FAK Phosphorylation and Potentiate the Antiproliferative Effects of Gemcitabine Through Modulation of the Human Equilibrative Nucleoside Transporter-1 in Peritoneal Mesothelioma |
Articolo in rivista |
Vai |
| 2020 |
Open Sesame? : Biomarker Status of the Human Equilibrative Nucleoside Transporter-1 and Molecular Mechanisms Influencing its Expression and Activity
in the Uptake and Cytotoxicity of Gemcitabine in Pancreatic Cancer |
Articolo in rivista |
Vai |
| 2020 |
Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry |
Capitolo o Saggio |
Vai |
| 2020 |
Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells |
Articolo in rivista |
Vai |
| 2020 |
Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds |
Articolo in rivista |
Vai |
| 2019 |
2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors |
Articolo in rivista |
Vai |
| 2019 |
Biological evaluation of new 1,2,4-oxadiazole topsentin analogs as anticancer agents |
Abstract in atti di convegno pubblicato in volume |
Vai |
| 2019 |
A Synthetic Derivative of Antimicrobial Peptide Holothuroidin 2 from Mediterranean Sea Cucumber (Holothuria tubulosa) in the Control of Listeria monocytogenes |
Articolo in rivista |
Vai |
| 2019 |
Synthesis of novel 1,2,4-oxadiazole topsentin analogs with antitumor activity |
Contributo in atti di convegno pubblicato in volume |
Vai |
| 2019 |
Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines |
Articolo in rivista |
Vai |
| 2019 |
Pharmacogenetics of treatments for pancreatic cancer |
Articolo in rivista |
Vai |
| 2019 |
Quality, functional and sensory evaluation of pasta fortified with extracts from Opuntia ficus-indica cladodes |
Articolo in rivista |
Vai |
| 2019 |
Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance |
Articolo in rivista |
Vai |
| 2019 |
β -Lactoglobulin Heptapeptide Reduces Oxidative Stress in Intestinal Epithelial Cells and Angiotensin II-Induced Vasoconstriction on Mouse Mesenteric Arteries by Induction of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Translocation |
Articolo in rivista |
Vai |
| 2019 |
Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives against Pancreatic Cancer Cells* |
Articolo in rivista |
Vai |
| 2019 |
New 1,2,4-Oxadiazole Nortopsentin Derivatives with Cytotoxic Activity |
Articolo in rivista |
Vai |
| 2018 |
Biofilm capability of staphylococcus strains isolated from food and the anti-biofilm activity of a chemically synthesized pyrrolomycin |
Articolo in rivista |
Vai |
| 2018 |
Proton-coupled folate transporter as a biomarker of outcome to treatment for pleural mesothelioma |
Articolo in rivista |
Vai |
| 2018 |
Synthesis of 5H-pyrido[3,2-b]pyrrolizin-5-one tripentone analogs with antitumor activity |
Articolo in rivista |
Vai |
| 2018 |
New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation |
Articolo in rivista |
Vai |
| 2018 |
A computational study to explore the molecular mechanisms behind the antiproliferative activity of Nortopsentin derivatives |
Proceedings |
Vai |
| 2018 |
Bacterial Biofilm Inhibition in the Development of Effective Anti-Virulence Strategy |
Articolo in rivista |
Vai |
| 2018 |
An overview of recent molecular dynamics applications as medicinal chemistry tools for the undruggable site challenge |
Articolo in rivista |
Vai |
| 2017 |
Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods |
Articolo in rivista |
Vai |
| 2017 |
Antibacterial Activity of Desert Truffles from Saudi Arabia Against Staphylococcus aureus and Pseudomonas aeruginosa |
Articolo in rivista |
Vai |
| 2017 |
Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues |
Articolo in rivista |
Vai |
| 2017 |
Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives |
Articolo in rivista |
Vai |
| 2017 |
Pyrrolo[3′,2′:6,7]cyclohepta[1,2-b]pyridines with potent photo-antiproliferative activity |
Articolo in rivista |
Vai |
| 2017 |
New Tripentone Analogs with Antiproliferative Activity |
Articolo in rivista |
Vai |
| 2017 |
New antimicrobial peptides from Tirmania pinoyi and Terfezia boudieri in the struggle against antibiotic resistance |
Proceedings |
Vai |
| 2017 |
An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds |
Articolo in rivista |
Vai |
| 2017 |
1,3,5-Triazines: A promising scaffold for anticancer drugs development |
Articolo in rivista |
Vai |
| 2017 |
Pharmaceutical Approaches to Target Antibiotic Resistance Mechanisms |
Articolo in rivista |
Vai |
| 2016 |
A new class of phenylhydrazinylidene derivatives as inhibitors of Staphylococcus aureus biofilm formation |
Articolo in rivista |
Vai |
| 2016 |
Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene)alkanoic acids and related derivatives |
Articolo in rivista |
Vai |
| 2016 |
A peptide from human β thymosin as a platform for the development of new anti-biofilm agents for Staphylococcus spp. and Pseudomonas aeruginosa |
Articolo in rivista |
Vai |
| 2016 |
Synthesis and antitumor activity of new thiazole nortopsentin analogs |
Articolo in rivista |
Vai |
| 2016 |
Quality characteristics and in vitro digestibility study of barley flour enriched ditalini pasta |
Articolo in rivista |
Vai |
| 2016 |
Synthesis and biofilm formation reduction of pyrazole-4-carboxamide derivatives in some Staphylococcus aureus strains |
Articolo in rivista |
Vai |
| 2015 |
Curcumin derivatives as inhibitors of Gram positive and Gram negative biofilm formation |
Proceedings |
Vai |
| 2015 |
Oregano essential oils activity against Listeria monocitogenes biofilms |
Proceedings |
Vai |
| 2015 |
Sortase A Inhibitors: Recent Advances and Future Perspectives |
Articolo in rivista |
Vai |
| 2015 |
Recent advanced in bioactive systems containing pyrazole fused with a five membered heterocycle |
Articolo in rivista |
Vai |
| 2015 |
Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality |
Articolo in rivista |
Vai |
| 2015 |
Discovery of a New Class of Sortase A Transpeptidase Inhibitors to Tackle Gram-positive
Pathogens: 2-Phenylhydrazonoalkanoic Acid Derivatives |
Proceedings |
Vai |
| 2015 |
Pharmaceutical potential of synthetic and natural pyrrolomycins |
Articolo in rivista |
Vai |
| 2015 |
New Anti-Adhesion Agents In The Development of Antivirulence Drugs |
Proceedings |
Vai |
| 2015 |
Synthesis and antiproliferative activity of 3-(2-cloroethyl)-5-methyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4-(3H)-one |
Articolo in rivista |
Vai |
| 2014 |
Paracentrin 1, a synthetic antimicrobial peptide fragment of a beta-thymosin from the sea-urchin Paracentrotus lividus, interferes with staphylococcal and Pseudomonas aeruginosa biofilm formation |
Proceedings |
Vai |
| 2014 |
Paracentrin1, a synthetic antimicrobial peptide fragment of a beta-thymosin from the sea-urchin Paracentrotus lividus, interferes whith staphylococcal and Pseudomonas aeruginosa biofilm formation |
Proceedings |
Vai |
| 2014 |
Synthesis and antiproliferative activity of a natural like glucosyl polycyclic compound |
Proceedings |
Vai |
| 2014 |
NUOVI DERIVATI 2-ACETAMMIDOBENZAMMIDICI:
ATTIVITÀ ANTIPROLIFERATIVA E POSSIBILE MECCANISMO DI AZIONE |
Proceedings |
Vai |
| 2014 |
Synthesis and antiproliferative activity of new derivatives containing the polycyclic system 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3’,4’:2,3]azepino[4,5-f]azocine |
Articolo in rivista |
Vai |
| 2014 |
Synthesis and antirpoliferative activity of isoxazolo[3,4-d]pyridazin-7(6H)-one derivatives |
Proceedings |
Vai |
| 2014 |
Sortase A: An ideal target for anti-virulence drug development |
Articolo in rivista |
Vai |
| 2014 |
Anti-adhesion agents against Gram-positive pathogens |
Articolo in rivista |
Vai |
| 2014 |
The future of antibiotic: From the magic bullet to the smart bullet |
Articolo in rivista |
Vai |
| 2014 |
ATTIVITÀ ANTIPROLIFERATIVA DI UN DERIVATO POLICICLICO CON STRUTTURA COMPLESSA |
Proceedings |
Vai |
| 2013 |
2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity and mechanism of action |
Proceedings |
Vai |
| 2012 |
Synthesis and anti-staphylococcal activity of new 4-diazopyrazole derivatives |
Articolo in rivista |
Vai |
| 2012 |
Synthesis and antioproliferative activity of new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine |
Proceedings |
Vai |
| 2011 |
Synthesis and antiproliferative activity of indazole derivatives |
Proceedings |
Vai |
| 2011 |
Synthesis of substituted 3-amino-N-phenyl-1H-indazole-1-carboxamides endowed with antiproliferative activity |
Articolo in rivista |
Vai |
| 2011 |
Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[2E]-3-phenylprop-2-enoylamino}benzamides |
Articolo in rivista |
Vai |
| 2011 |
Synthesis, antiproliferative activity, and mechanism of action of new benzamido derivatives |
Proceedings |
Vai |
| 2010 |
SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF 3-AMINO-N-PHENYL-1H-INDAZOLE-1-CARBOXAMIDES |
Proceedings |
Vai |
| 2010 |
Pyrazolobenzotriazinones Derivatives as COX Inhibitors: Synthesis Biological Activity and Molecular Modeling Studies |
Articolo in rivista |
Vai |
| 2010 |
Pyrrolomycins as potential anti-staphylococcal biofilms agents |
Articolo in rivista |
Vai |
| 2010 |
Novel chemical countermeasures against staphylococcal biofilms |
Proceedings |
Vai |
| 2009 |
Pyrazolo[3,4-d]pyrimidine Derivatives as COX-2 Selective Inhibitors: Synthesis and Molecular Modelling Studies |
Articolo in rivista |
Vai |
| 2009 |
N-(INDAZOLYL)BENZAMIDO DERIVATIVES AS CDK1 INHIBITORS: DESIGN, SYNTHESIS, BIOLOGICAL ACTIVITY, AND MOLECULAR DOCKING STUDIES |
Articolo in rivista |
Vai |
| 2009 |
Synthesis and antiproliferative activity of 3-amino-N-phenyl-1H-indazole-1-carboxamides |
Articolo in rivista |
Vai |
| 2009 |
Synthesis and biological evaluation of some new 2-phenylpropiolamidobenzamides as potential antagonists of the HDM2-p53 protein-protein interactions |
Proceedings |
Vai |
| 2009 |
Pyrrolomycins as novel agents against staphylococcal biofilms |
Proceedings |
Vai |
| 2008 |
4-Diazopyrazole Derivatives as Potential New Antibiofilm Agents |
Articolo in rivista |
Vai |
| 2008 |
Synthesis and induction of G0-G1 phase arrest with apoptosis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one |
Articolo in rivista |
Vai |
| 2008 |
SYNTHETIC AND BIOLOGICAL EVALUATION OF SOME NEW 2-CINNAMAMIDOBENZAMIDES AS POTENTIAL ANTAGONIST OF THE HDM2-P53 PROTEIN-PROTEIN INTERACTIONS |
Proceedings |
Vai |
| 2008 |
In vitro anti-Gram-positive and anti-staphylococcal biofilm activity of newly halogenated pyrroles related to Pyrrolomycins |
Articolo in rivista |
Vai |
| 2008 |
Comparative studies of the Pschorr reaction in the pyrazole series. Access to the new dibenzo(e,g)pyrazolo(1,5-a)(1,3)diazocine system of pharmaceutical interest |
Articolo in rivista |
Vai |
| 2007 |
Synthesis and antiproliferative activity of 3-amino-N-phenyl-1H-indazole-1-carboxamide derivatives |
Proceedings |
Vai |
| 2007 |
Synthesis and biological evaluation of new 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides |
Proceedings |
Vai |
| 2007 |
Synthesis and anticancer activity of 3-amino-N-phenyl-1H-indazole-1-carboxamide and 1-(1H)indazol-3-yl-3-phenylureido derivatives |
Proceedings |
Vai |
| 2007 |
Synthesis and induction of G0-G1 phase arrest with apoptosis of 3,5-dimethyl-6-phenyl-8-trifluoromethyl-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4-one |
Proceedings |
Vai |
| 2007 |
Antileukemic activity of some new 3-amino-N-phenyl-(1H)-indazole-1-carboxamide derivatives |
Proceedings |
Vai |
| 2006 |
Synthesis of New Pyrazole Derivatives as Potential CDK1 Inhibitors |
Proceedings |
Vai |
| 2006 |
Synthesis of New Indazol-3-yl derivatives as CDK1 inhibitors |
Proceedings |
Vai |
| 2006 |
CDK: LigandFit Enrichment Plot of Active Compounds in a Screening Dataset. |
Proceedings |
Vai |
| 2006 |
Synthesis and Antiproliferative Activity of a New Pyrazolo[3,4-f]1,2,3,5-tetrazepin-4(3H)-one Derivative |
Proceedings |
Vai |
| 2006 |
Synthesis of alkyl-5,8-dimethyl-6-phenyl-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-ones of pharmaceutical interest |
Articolo in rivista |
Vai |
| 2006 |
Synthesis and antimicrobial activity of new bromine-rich pyrrole derivatives related to monodeoxypyoluteorin |
Articolo in rivista |
Vai |
| 2005 |
BENZOTRIAZINONE AND QUINAZOLINONE DERIVATIVES AS COX-INHIBITORS: COMPUTATIONAL STUDIES |
Proceedings |
Vai |
| 2004 |
Synthesis and antileukemic activity of new 3-(5-methylisoxazol-3-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones. |
Articolo in rivista |
Vai |
| 2004 |
SYNTHESIS AND ANTILEUKEMIC ACTIVITY OF NEW 3-(1-PHENYL-3-METHYLPYRAZOL-5-YL)-2-STYRYLQUINAZOLIN-4(3H)-ONES |
Articolo in rivista |
Vai |
