Synthesis and antioproliferative activity of new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine
- Autori: Maggio,B; Raffa, D; Raimondi, MV; Plescia, F; Cusimano, MG; Schillaci, D; Cancemi, G; Cascioferro, SM; Daidone G
- Anno di pubblicazione: 2012
- Tipologia: Proceedings
- OA Link: http://hdl.handle.net/10447/78181
Abstract
By reacting methylaminopyrazoles with hexane-2,5-dione in 1,4-dioxane in the presence of p-toluensulfonic acid, new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine were obtained. The new synthesized compounds were tested preliminarly at 10 microM against five human cancer cell lines showing a range of inhibition of 20-62% against the most susceptible cell lines K562 and HCT116.