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MATILDE TODARO

Curriculum e ricerca

Insegnamenti

Anno accademico Codice della materia Nome della materia CFU Corso di studi
2024/2025 22311 METODOLOGIA DELLA RICERCA E DELL’INNOVAZIONE C.I. 9 SCIENZE DELLE PROFESSIONI SANITARIE TECNICHE DIAGNOSTICHE
2024/2025 23002 METODOLOGIA DELLA RICERCA SCIENTIFICA C.I. 11 SCIENZE DELLE PROFESSIONI SANITARIE DELLA PREVENZIONE
2024/2025 05547 PATOLOGIA GENERALE 3 FISIOTERAPIA (ABILITANTE ALLA PROFESSIONE SANITARIA DI FISIOTERAPISTA)
2024/2025 22991 RICERCA CLINICA ED EBM (MODULO) 4 SCIENZE DELLE PROFESSIONI SANITARIE DELLA PREVENZIONE
2024/2025 24125 RICERCA SCIENTIFICA APPLICATA ALLA CLINICA (MODULO) 2 SCIENZE RIABILITATIVE DELLE PROFESSIONI SANITARIE
2024/2025 22027 SCIENZE LOGOPEDICHE DI BASE 4 LOGOPEDIA (ABILITANTE ALLA PROFESSIONE SANITARIA DI LOGOPEDISTA)
2024/2025 22058 SCIENZE RIABILITATIVE II C.I. 4 SCIENZE RIABILITATIVE DELLE PROFESSIONI SANITARIE
2024/2025 22050 SCIENZE TECNICHE MEDICHE APPLICATE (MODULO) 2 LOGOPEDIA (ABILITANTE ALLA PROFESSIONE SANITARIA DI LOGOPEDISTA)
2024/2025 22289 TECNOLOGIA DELLA RICERCA SCIENTIFICA (MODULO) 3 SCIENZE DELLE PROFESSIONI SANITARIE TECNICHE DIAGNOSTICHE

Pubblicazioni

Data Titolo Tipologia Scheda
2024 Protocol for generation and engineering of thyroid cell lineages using CRISPR-Cas9 editing to recapitulate thyroid cancer histotype progression Articolo in rivista Vai
2024 Lipid droplets and small extracellular vesicles: More than two independent entities Articolo in rivista Vai
2024 Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory Articolo in rivista Vai
2023 Recapitulating thyroid cancer histotypes through engineering embryonic stem cells Articolo in rivista Vai
2023 Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation Articolo in rivista Vai
2023 EBF1, MYO6 and CALR expression levels predict therapeutic response in diffuse large B-cell lymphomas Articolo in rivista Vai
2022 Targeting epigenetic alterations in cancer stem cells Review essay (rassegna critica) Vai
2022 Dual Inhibition of Myc Transcription and PI3K Activity Effectively Targets Colorectal Cancer Stem Cells Articolo in rivista Vai
2022 Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51 Articolo in rivista Vai
2022 Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy Review essay (rassegna critica) Vai
2022 Destroying the Shield of Cancer Stem Cells: Natural Compounds as Promising Players in Cancer Therapy Review essay (rassegna critica) Vai
2022 Cancer cell targeting by CAR-T cells: A matter of stemness Review essay (rassegna critica) Vai
2021 Interleukin-30 feeds breast cancer stem cells via CXCL10 and IL23 autocrine loops and shapes immune contexture and host outcome Articolo in rivista Vai
2021 Messing Up the Cancer Stem Cell Chemoresistance Mechanisms Supported by Tumor Microenvironment Review essay (rassegna critica) Vai
2021 The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs Articolo in rivista Vai
2021 Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy Articolo in rivista Vai
2021 Targeting Phosphatases and Kinases: How to Checkmate Cancer Articolo in rivista Vai
2021 Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery Articolo in rivista Vai
2021 PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells Articolo in rivista Vai
2021 CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin Articolo in rivista Vai
2021 Magnetic Nanoparticle-Based Hyperthermia Mediates Drug Delivery and Impairs the Tumorigenic Capacity of Quiescent Colorectal Cancer Stem Cells Articolo in rivista Vai
2020 Metabolic Escape Routes of Cancer Stem Cells and Therapeutic Opportunities Review essay (rassegna critica) Vai
2020 Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant Articolo in rivista Vai
2020 ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells Articolo in rivista Vai
2020 Cancer Stem Cells in Thyroid Tumors: From the Origin to Metastasis Articolo in rivista Vai
2019 Correction to: Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4 (Cell Death & Differentiation, (2008), 15, 4, (762-772), 10.1038/sj.cdd.4402305) Nota o commento Vai
2019 Accumulation of Circulating CCR7+ Natural Killer Cells Marks Melanoma Evolution and Reveals a CCL19-Dependent Metastatic Pathway Articolo in rivista Vai
2019 Erratum: By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy Articolo in rivista Vai
2019 Cancer Stem Cells: From Birth to Death Capitolo o Saggio Vai
2019 Meeting the Challenge of Targeting Cancer Stem Cells Articolo in rivista Vai
2018 Microenvironment in neuroblastoma: Isolation and characterization of tumor-derived mesenchymal stromal cells Articolo in rivista Vai
2018 MiR-205-5p inhibition by locked nucleic acids impairs metastatic potential of breast cancer cells Articolo in rivista Vai
2018 Capturing Colorectal Cancer Inter-Tumor Heterogeneity in Patient-Derived Xenograft (PDX) Models Articolo in rivista Vai
2018 MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state Articolo in rivista Vai
2017 Squamous cell tumors recruit γδ T cells producing either IL17 or IFNγ depending on the tumor stage Articolo in rivista Vai
2017 Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma Articolo in rivista Vai
2017 MiR-24 induces chemotherapy resistance and hypoxic advantage in breast cancer Articolo in rivista Vai
2017 Distinctive features of tumor-infiltrating gd T lymphocytes in human colorectal cancer Articolo in rivista Vai
2017 Innovative Therapeutic Strategies Targeting Colorectal Cancer Stem Cells Recensione in rivista Vai
2017 PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer Articolo in rivista Vai
2017 Role of Type I and II interferons in colorectal cancer and melanoma Recensione in rivista Vai
2017 IL4 primes the dynamics of breast cancer progression via DUSP4 inhibition Articolo in rivista Vai
2016 Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform. Articolo in rivista Vai
2016 Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers Articolo in rivista Vai
2016 ΔNp63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis Articolo in rivista Vai
2016 Targeting dna double strand break repair with hyperthermia and dna-pkcs inhibition to enhance the effect of radiation treatment Articolo in rivista Vai
2016 Activated thyroid hormone promotes differentiation and chemotherapeutic sensitization of colorectal cancer stem cells by regulating Wnt and BMP4 signaling Articolo in rivista Vai
2016 MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b Articolo in rivista Vai
2016 p63 role in breast cancer Articolo in rivista Vai
2015 Dynamic regulation of the cancer stem cell compartment by Cripto-1 in colorectal cancer Articolo in rivista Vai
2015 Targeting cancer stem cells and the tumor microenvironment Capitolo o Saggio Vai
2015 miR-205-5p-mediated downregulation of ErbB/HER receptors in breast cancer stem cells results in targeted therapy resistance Articolo in rivista Vai
2015 Lipid droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging Articolo in rivista Vai
2015 By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy Articolo in rivista Vai
2015 A BMP7 variant inhibits tumor angiogenesis in vitro and in vivo through direct modulation of endothelial cell biology Articolo in rivista Vai
2015 TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells Articolo in rivista Vai
2015 Normal vs cancer thyroid stem cells: the road to transformation Recensione in rivista Vai
2015 Cancer Stem Cells Sensitivity Assay (STELLA) in Patients with Advanced Lung and Colorectal Cancer: A Feasibility Study. Articolo in rivista Vai
2014 Colorectal Cancer Stem Cells: From the Crypt to the Clinic Articolo in rivista Vai
2014 CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis Articolo in rivista Vai
2014 Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer Articolo in rivista Vai
2014 p63 isoforms regulate metabolism of cancer stem cells Articolo in rivista Vai
2014 Estrogens and stem cells in thyroid cancer Articolo in rivista Vai
2014 Colorectal cancer defeating? Challenge accepted! Recensione in rivista Vai
2014 Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment Articolo in rivista Vai
2014 γδ T cells as a potential tool in colon cancer immunotherapy Articolo in rivista Vai
2013 Erythropoietin activates cell survival pathways in breast cancer stem-like cells to protect them from chemotherapy Articolo in rivista Vai
2013 Combining conventional chemotherapy and γδ T cell-based immunotherapy to target cancer-initiating cells. Articolo in rivista Vai
2013 Mechanisms underlying lineage commitment and plasticity of human γδ T cells. Articolo in rivista Vai
2013 Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules Articolo in rivista Vai
2013 Cancer-Initiating Cells from Colorectal cancer Patients Escape from T Cell-Mediated Immunosurveillance In Vitro through Membrane-Bound IL-4 Articolo in rivista Vai
2013 Tumor and its microenvironment: a synergistic interplay. Recensione in rivista Vai
2013 Chemotherapy Sensitizes Colon Cancer Initiating Cells to Vc9Vd2 T Cell-Mediated Cytotoxicity Articolo in rivista Vai
2013 Distribution, function and predictive value of tumor-infiltrating γδ T lymphocytes Articolo in rivista Vai
2012 INTRODUCING NON-ADHERENT PROGENITORS FROM ADIPOSE-DERIVED STEM CELLS (NAPADSCS): PROOF OF STEMNESS AND POSSIBLE FUTURE APPLICATIONS IN REGENERATIVE SURGERY Abstract in rivista Vai
2012 Characterization of human γδ T lymphocytes infiltrating primary malignant melanomas Articolo in rivista Vai
2012 CD133 as a target for colon cancer. Articolo in rivista Vai
2012 Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells. Articolo in rivista Vai
2012 ADHESION AND OSTEOGENIC DIFFERENTIATION OF NON-ADHERENT PROGENITORS FROM ADIPOSE-DERIVED STEM CELLS (napASCs) OVER INTEGRA DERMAL REGENERATION TEMPLATE Abstract in rivista Vai
2012 IL-21 regulates the differentiation of a human γδ T cell subset equipped with B cell helper activity. Articolo in rivista Vai
2011 DOWN REGULATION OF LYMPHOCYTES APOPTOSIS IN GIRLS WITH PRECOCIOUS PUBERTY Poster pubblicato in rivista Vai
2011 Colorectal cancer stem cells and cell death Review essay (rassegna critica) Vai
2011 Immunotherapy targeting colon cancer stem cells Recensione in rivista Vai
2011 Prevention of Chemotherapy-Induced Anemia and Thrombocytopenia by Constant Administration of Stem Cell Factor Articolo in rivista Vai
2011 Colon Cancer Stem Cells: Bench-to-Bedside—New Therapeutical Approaches in Clinical Oncology for Disease Breakdown Recensione in rivista Vai
2011 Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice. Articolo in rivista Vai
2011 Differentiation, phenotype, and function of interleukin-17-producing human V{gamma}9V{delta}2 T cells Articolo in rivista Vai
2010 V{gamma}9V{delta}2 T Lymphocytes Efficiently Recognize and Kill Zoledronate-Sensitized, Imatinib-Sensitive, and Imatinib-Resistant Chronic Myelogenous Leukemia Cells. Articolo in rivista Vai
2010 Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells Articolo in rivista Vai
2010 Survivin is regulated by interleukin-4 in colon cancer stem cells Articolo in rivista Vai
2010 In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Articolo in rivista Vai
2010 Aurora-a is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells. Articolo in rivista Vai
2010 Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Articolo in rivista Vai
2010 Evidences of cervical cancer stem cells derived from established cell lines. Articolo in rivista Vai
2010 Colon cancer stem cells: promise of targeted therapy. Articolo in rivista Vai
2010 Tumorigenic and metastatic activity of human thyroid cancer stem cells Articolo in rivista Vai
2009 Role of interleukin-4 on colon cancer stem cell survival Proceedings Vai
2009 Therapeutic implications of Cancer Initiating Cells. Articolo in rivista Vai
2009 P-Selectin Glycoprotein Ligand-1 as a Potential Target for Humoral Immunotherapy of Multiple Myeloma Articolo in rivista Vai
2009 Suppressor of cytokine signaling 3 sensitizes anaplastic thyroid cancer to standard chemotherapy Articolo in rivista Vai
2009 Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes Articolo in rivista Vai
2008 Crucial role of interleukin-4 in the survival of colon cancer stem cells Articolo in rivista Vai
2008 Isolation and culture of colon cancer stem cells. Articolo in rivista Vai
2008 Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Articolo in rivista Vai
2008 Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure. Articolo in rivista Vai
2008 Galectin-3 immunodetection for improving the performance of conventional thyroid cytology: preliminay results Proceedings Vai
2008 Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme Articolo in rivista Vai
2008 Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4 Articolo in rivista Vai
2008 IL-4-mediated drug resistance in colon cancer stem cells Articolo in rivista Vai
2007 ANTIBODY SPECIFIC FOR HUMAN IL-4 FOR THE TREAMENT OF CANCER Brevetto Vai
2007 Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production of Interleukin-4 Articolo in rivista Vai
2007 MUC1 Oncoprotein Promotes Refractoriness to Chemotherapy in Thyroid Cancer Cells Articolo in rivista Vai
2007 Role of Th cytokines in thyroid autoimmunity Articolo in rivista Vai
2007 Identification and expansion of human colon-cancer-initiating cells. Articolo in rivista Vai
2006 Comparative study of T84 and T84SF human colon carcinoma cells: in vitro and in vivo ultrastructural and functional characterization of cell culture and metastasis Articolo in rivista Vai
2006 Thyroid stem cells: phenotypic properties, differentiation, potential and regulation by bone morphogenetic proteins Proceedings Vai
2006 Autocrine production of IL-4 confers resistance to chemotherapy and CD-95 induced cell death in cancer cells. Proceedings Vai
2006 Autocrine production of interleukin-4 and interleukin-10 is required for survival and growth of thyroid cancer cells Articolo in rivista Vai
2006 Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis. Articolo in rivista Vai
2006 Involvement of MUC1 oncoprotein in thyroid cancer resistance to chemoterapeutic drugs Proceedings Vai
2006 Optimisation of cancer therapy by sensitization of cancer stem cells within tumorsto death indicing regimens Proceedings Vai
2006 Sensitizing cells for apoptosis by selectively blocking cytokines. Brevetto Vai
2006 CANCER STEM CELLS CONTRIBUTE TO THE AGGRESSIVE BEHAVIOUR OF HUMAN EPITHELIAL COLON CANCER. Proceedings Vai
2005 OSSERVAZIONi A PROPOSITO DI UN CASO DI CISTI GIGANTE DELLA MILZA Traduzione in rivista Vai
2005 ROLE OF IL-4 AND IL-10 CYTOKYNES IN THE PATHOGENIC MECHANISM OF THYROID CANCER Capitolo o Saggio Vai
2005 PED/PEA-15 mediates AKT dependent chemoresistance in human breast cancer cells Proceedings Vai
2005 Il follow-up della tiroidectomia totale dei carcinomi differenziati della tiroide Proceedings Vai
2005 PED Mediates AKT-Dependent Chemoresistance in Human Breast Cancer Cells Articolo in rivista Vai
2004 Cosa c'è di nuovo nel trattamento del carcinoma differenziato della tiroide Proceedings Vai
2004 CD95 DISC formation and internalizzation occur in lipid rafts of typeI and typeII cells Articolo in rivista Vai
2004 METHOD FOR THE PURIFICATION AND AMPLIFICATION OF TUMORAL STEM CELLS Brevetto Vai
2004 SENSITIZING CELLS FOR APOPTOSIS BY SELECTIVELY BLOCKING CYTOKINES Brevetto Vai
2004 Role of apoptosis in autoimmunity Articolo in rivista Vai
2004 Metodo per la purificazione e l’ampliamento di cellule staminali tumorali Brevetto Vai
2004 Th2 cytokines induce chemotherapy resistance in epithelial tumors via PI3K/AKT pathway Proceedings Vai
2003 Thyroid Cancer Resistance to Chemotherapeutic Drugs via Autocrine Production of Interleukin-4 and Interleukin-10 Articolo in rivista Vai
2003 Islet Beta-Cell Apoptosis Triggered in Vivo by Interleukin-1 Is Not Related to the Inducible Nitric Oxide Synthase Pathway: Evidence for Mitochondrial Function Impairment and Lipoperoxidation Articolo in rivista Vai
2002 High Levels of Exogenous C2-Ceramide Promote Morphological and Biochemical Evidences of Necrotic Features in Thyroid Follicular Cells Articolo in rivista Vai
2000 Involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in Farber disease Articolo in rivista Vai
1999 Defective apoptosis as potential mechanism in the tumorogenesis of myelolipoma Articolo in rivista Vai