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VIRGINIA SPANO'

Curriculum and Research

SPANO' VIRGINIA

VIRGINIA SPANO'

 (CHEM-07/A)

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Contacts

+3909123896827

virginia.spano@unipa.it

Curriculum not available

Subjects

Academic Year Subject identification code Subject name ECTS Course of study
2024/2025 01211 ANALISI DEI MEDICINALI 10 CHIMICA E TECNOLOGIA FARMACEUTICHE

Publications

Date Title Type Record
2024 Identification of 6,9-dihydro-5H-pyrrolo[3,2-h]quinazolines as a new class of F508del-CFTR correctors for the treatment of cystic fibrosis Articolo in rivista Go to
2024 Citrus wastewater as a source of value‐added products: Quali‐quantitative analysis and in vitro screening on breast cancer cell lines Articolo in rivista Go to
2024 Chaperoning system: Intriguing target to modulate the expression of CFTR in cystic fibrosis Review essay (rassegna critica) Go to
2023 Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel Articolo in rivista Go to
2023 Editorial: Emerging heterocycles as bioactive compounds Nota o commento Go to
2023 Identification of pyrrolo[3′,4’:3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas Articolo in rivista Go to
2023 Exploring the anticancer activity and the mechanism of action of pyrrolomycins F obtained by microwave-assisted total synthesis Articolo in rivista Go to
2023 Insight into non-nucleoside triazole-based systems as viral polymerases inhibitors Review essay (rassegna critica) Go to
2022 GPCR Inhibition in Treating Lymphoma Review essay (rassegna critica) Go to
2022 Synthesis of 2H-Imidazo[2′,1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations Articolo in rivista Go to
2022 New tricyclic systems as photosensitizers towards triple negative breast cancer cells Articolo in rivista Go to
2022 The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma Articolo in rivista Go to
2022 Transcriptome and computational analysis assess the anti-tubulin activity of [1,2]oxazole derivatives in lymphoma Abstract in atti di convegno pubblicato in rivista Go to
2022 Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells Articolo in rivista Go to
2022 Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line Articolo in rivista Go to
2022 Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas Articolo in rivista Go to
2021 Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds Review essay (rassegna critica) Go to
2021 NEW THERAPEUTIC AGENTS FOR THE TREATMENT OF HAEMATOLOGICAL PATHOLOGIES Brevetto Go to
2021 THE KEY ROLE OF THE CLINICAL PHARMACIST IN THE MANAGEMENT OF ANTICANCER THERAPIES: A PILOT STUDY IN THE TREATMENT OF PATIENTS WITH NON-SMALL CELL LUNG CANCER Articolo in rivista Go to
2021 Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors Articolo in rivista Go to
2021 Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity Review essay (rassegna critica) Go to
2021 Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein Articolo in rivista Go to
2020 Current development of CFTR potentiators in the last decade Articolo in rivista Go to
2020 Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes Articolo in rivista Go to
2020 Pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types Articolo in rivista Go to
2020 Bioactive pyrrole-based compounds with target selectivity Articolo in rivista Go to
2020 Evaluation of [1,2]oxazolo[5,4-e]isoindoles in lymphoma cells Abstract in atti di convegno pubblicato in rivista Go to
2019 Targeting Multiple Myeloma with natural polyphenols Review essay (rassegna critica) Go to
2019 Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines Articolo in rivista Go to
2019 HETEROCYCLIC COMPOUNDS AND MEDICAL USE THEREOF Brevetto Go to
2019 NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DI PATOLOGIE EMATOLOGICHE Brevetto Go to
2019 Furocoumarins as multi-target agents in the treatment of cystic fibrosis Review essay (rassegna critica) Go to
2019 Quality, functional and sensory evaluation of pasta fortified with extracts from Opuntia ficus-indica cladodes Articolo in rivista Go to
2019 An overview on chemical structures as ΔF508-CFTR correctors Review essay (rassegna critica) Go to
2018 New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation Articolo in rivista Go to
2018 Synthesis of 5H-pyrido[3,2-b]pyrrolizin-5-one tripentone analogs with antitumor activity Articolo in rivista Go to
2017 Composti a struttura ossazolica, procedimenti per la loro produzione e loro impiego per la cura di patologie a carattere iperproliferativo Brevetto Go to
2017 Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods Articolo in rivista Go to
2017 Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues Articolo in rivista Go to
2017 Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives Articolo in rivista Go to
2017 Pharmaceutical Approaches to Target Antibiotic Resistance Mechanisms Articolo in rivista Go to
2017 New Tripentone Analogs with Antiproliferative Activity Articolo in rivista Go to
2017 An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds Articolo in rivista Go to
2017 1,3,5-Triazines: A promising scaffold for anticancer drugs development Articolo in rivista Go to
2017 Pyrrolo[3′,2′:6,7]cyclohepta[1,2-b]pyridines with potent photo-antiproliferative activity Articolo in rivista Go to
2016 Synthesis and antiproliferative mechanism of action of pyrrolo[3′,2′:6,7] cyclohepta[1,2-d]pyrimidin-2-amines as singlet oxygen photosensitizers Articolo in rivista Go to
2016 Synthesis and antitumor activity of new thiazole nortopsentin analogs Articolo in rivista Go to
2016 4,5,6,9-tetraidropirrolo[2',3':3,4] cicloepta[1,2-d] isossazoli, procedimento per la loro produzione e loro uso come antitumorali Brevetto Go to
2016 NUOVI COMPOSTI PIRAZOLO[3,4-H]CHINOLINICI, LORO PREPARAZIONE ED USO MEDICO Brevetto Go to
2016 Quality characteristics and in vitro digestibility study of barley flour enriched ditalini pasta Articolo in rivista Go to
2016 Synthesis and antitumor activity of new 7-azaindole derivative nortopsentin analogues Abstract in atti di convegno pubblicato in volume Go to
2016 Pyrrolocycloheptaoxazole as potent antitumor agents Abstract in atti di convegno pubblicato in volume Go to
2016 [1,2]Oxazolo[5,4-e]isoindoles as promising tubulin polymerization inhibitors Articolo in rivista Go to
2016 4,5,6,9-TETRAHYDROPYRROLO[2',3'-3,4]CYCLOEPTA[1,2-d]ISOSSAZOLE, PROCESS FOR THEIR PRODUCTION AND THEIR USES AS ANTITUMOR AGENTS Brevetto Go to
2016 Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma Articolo in rivista Go to
2015 Quality characteristic and in vitro digestibility study of barley flour enriched ditalini pasta Proceedings Go to
2015 Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest Articolo in rivista Go to
2015 Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action Articolo in rivista Go to
2015 3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin Analogues with antiproliferative activity Articolo in rivista Go to
2015 Synthesis and antiproliferative activity of thiazolyl-bis-pyrrolo[2,3-b]pyridines and indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, nortopsentin analogues Articolo in rivista Go to
2015 Pyrazolo[3,4-h]quinolines promising photosensitizing agents in the treatment of cancer Articolo in rivista Go to
2015 Aza-isoindolo and isoindolo-azaquinoxaline derivatives with antiproliferative activity Articolo in rivista Go to
2015 [1,2]oxazole[5,4-e]isoindoles as promising drugs for anticancer chemotherapy Proceedings Go to
2014 Synthesis of the New Ring System Bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and Its Deaza Analogue Articolo in rivista Go to
2014 Synthesis and antiproliferative activity of substituted 3[2-(1H-indol-3-yl)-1,3-thiazol-4-yl]-1H-pyrrolo[3,2-b]pyridines, marine alkaloid nortopsentin analogues Articolo in rivista Go to
2014 Synthesis and biological evaluation of pyrrolo[3’,2’:6,7]cyclohepta[1,2-d]pyrimidin-2-amines Proceedings Go to
2014 ‘Interrupted’ diazotization of 3-aminoindoles and 3-aminopyrroles Articolo in rivista Go to
2014 In vitro digestion of beta glucan enriched pasta and antioxidant potential of digesta Proceedings Go to
2014 In vitro digestion of beta glucan enriched pasta: polysaccharide molecular characterization and antioxidant activity of bioaccessible fraction. Proceedings Go to
2014 11H‑Pyrido[3′,2′:4,5]pyrrolo[3,2‑c]cinnoline and Pyrido[3′,2′:4,5]pyrrolo[1,2‑c][1,2,3]benzotriazine: Two New Ring Systems with Antitumor Activity Articolo in rivista Go to
2014 Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity Articolo in rivista Go to
2014 Synthesis of substituted isoindolo[2,1-a]quinoxalin-6-yl–amino and 6-imino-5-yl thiourea derivatives Articolo in rivista Go to
2013 Convenient synthesis of pyrrolo[3,4-g]indazole Articolo in rivista Go to
2013 A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin Articolo in rivista Go to
2013 2-substituted-[1,3]thiazolo[4,5-e]isoindoles as kinases inhibiting compounds Proceedings Go to
2013 Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin Articolo in rivista Go to
2013 Pyrazolo[3,4-h]quinolines as potent photosensitizer agents Proceedings Go to
2013 Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents Articolo in rivista Go to
2013 Pirazolo[3,4-h]chinoline come nuova classe di agenti fotosensibilizzanti Proceedings Go to
2013 Synthesis of the new oligopeptide pyrrole derivative isonetropsin and its one pyrrole unit analogue Articolo in rivista Go to
2013 Novel 1H‑Pyrrolo[2,3‑b]pyridine Derivative Nortopsentin Analogues: Synthesis and Antitumor Activity in Peritoneal Mesothelioma Experimental Models Articolo in rivista Go to
2012 Synthesis and Antiproliferative Activity of the Ring System[1,2]Oxazolo[4,5-g]indole Articolo in rivista Go to
2012 An efficient synthesis of pyrrolo[3',2':4,5]thiopyrano[3,2-b]pyridin-2-one: a new ring system of pharmaceutical interest Articolo in rivista Go to
2012 Biological evaluation of Pyrrolo[3,4-h]quinazolines Proceedings Go to
2012 Pyrazolo[3,4-h]quinolin-2-ones with photobiological properties Proceedings Go to
2012 Synthesis of pyrazolo[4,3-c][1,2,6]benzothiadiazocine,a new ring system as potential COX inhibitor Articolo in rivista Go to
2012 New topoisomerase I inhibitors with condensed-azaindole structure Proceedings Go to
2011 Isoxazolo[5,4-e]isoindole a new ring system with potent antitumor activity Proceedings Go to
2010 PYRROLO[3,4-H]QUINAZOLINES WITH ANTITUMOR ACTIVITY Proceedings Go to
2009 Pyrano[2,3-e]isoindol-2-ones, new angelicin heteroanalogues Articolo in rivista Go to
2009 Synthesis of the new ring system 6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline Articolo in rivista Go to
2008 SYNTHESIS AND PHOTOBIOLOGICAL ACTIVITY OF PYRROLO-FUSED HETEROCYCLES Proceedings Go to
2008 ISOXAZOLO[5,4-E]ISOINDOLE: A NEW RING SYSTEM WITH POTETIAL PHOTOBIOLOGICAL PROPERTIES Proceedings Go to
2008 Pyrrolo-fused heterocycles as photochemotherapeutic agents Proceedings Go to
2007 SYNTHESIS OF PYRROLO[3,4-H]QUINAZOLIN-2-ONE A NEW RING SYSTEM WITH POTENTIAL PHOTOTHERAPEUTIC ACTIVITY Proceedings Go to
2007 SINTESI DI NUOVI DERIVATI[2,3-E]ISOINDOL-2-ONI A POTENZIALE ATTIVITA' FOTOCHEMIOTERAPICA Proceedings Go to
2006 A Convenient Synthesis of Pyrano[2,3-e]isoindol-2-one : a new heteroanalogue of angelicin Proceedings Go to
2006 PYRANO[2,3-E]ISOINDOL-2-ONE: A NEW RING SYSTEM WITH POTENTIAL PHOTOBIOLOGICAL PROPERTIES Proceedings Go to