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Pari opportunità

BARBARA PARRINO

Curriculum and Research

PARRINO BARBARA

BARBARA PARRINO

 (CHEM-07/A)

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Contacts

+3909123897413

barbara.parrino@unipa.it

Curriculum not available

Subjects

Academic Year Subject identification code Subject name ECTS Course of study
2024/2025 01205 ANALISI DEI FARMACI 10 CHIMICA E TECNOLOGIA FARMACEUTICHE

Publications

Date Title Type Record
2024 Exploring the therapeutic potential of focal adhesion kinase inhibition in overcoming chemoresistance in pancreatic ductal adenocarcinoma Review essay (rassegna critica) Go to
2024 Triazole derivatives inhibit the VOR complex-mediated nuclear transport of extracellular particles: Potential application in cancer and HIV-1 infection Articolo in rivista Go to
2024 Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: synthesis, mechanistic insights and promising antitumor and safety profile Articolo in rivista Go to
2024 Novel [1,3,4]Thiadiazole[3,2-a]pyrimidin-5-ones as Promising Biofilm Dispersal Agents against Relevant Gram-Positive and Gram-Negative Pathogens Articolo in rivista Go to
2023 1,2,4-Amino-triazine derivatives as pyruvate dehydrogenase kinase inhibitors: Synthesis and pharmacological evaluation Articolo in rivista Go to
2023 Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What is New? Articolo in rivista Go to
2023 A Combination of Polymethoxyflavones from Citrus sinensis and Prenylflavonoids from Humulus lupulus Counteracts IL-1β-Induced Differentiated Caco-2 Cells Dysfunction via a Modulation of NF-κB/Nrf2 Activation Articolo in rivista Go to
2023 Discovery of the 3-Amino-1,2,4-triazine-Based Library as Selective PDK1 Inhibitors with Therapeutic Potential in Highly Aggressive Pancreatic Ductal Adenocarcinoma Articolo in rivista Go to
2023 Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma Articolo in rivista Go to
2023 Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy Articolo in rivista Go to
2023 Nortopsentins as Leads from Marine Organisms for Anticancer and Anti-Inflammatory Agent Development Review essay (rassegna critica) Go to
2023 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1 Articolo in rivista Go to
2022 Eight-Membered Rings With Two Heteroatoms 1,3 Capitolo o Saggio Go to
2022 Eight-Membered Rings With Two Heteroatoms 1,2 Capitolo o Saggio Go to
2022 Eight-Membered Rings With Two Heteroatoms 1,5 Capitolo o Saggio Go to
2022 Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification Articolo in rivista Go to
2022 A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells Articolo in rivista Go to
2022 Eight-membered heterocycles with two heteroatoms in a 1,3-relationship of interest in medicinal chemistry Capitolo o Saggio Go to
2021 Therapeutic strategies to counteract antibiotic resistance in MRSA biofilm-associated infections Review essay (rassegna critica) Go to
2021 1,2,4-Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase Articolo in rivista Go to
2021 Dynamic-shared pharmacophore approach as tool to design new allosteric PRC2 inhibitors, targeting EED binding pocket Articolo in rivista Go to
2021 1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A Articolo in rivista Go to
2021 Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation Articolo in rivista Go to
2021 Novel strategies in the war against antibiotic resistance Articolo in rivista Go to
2021 SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance Articolo in rivista Go to
2021 Eight-membered heterocycles with two heteroatoms in a 1,2-relationship of interest in medicinal chemistry Capitolo o Saggio Go to
2021 Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum Articolo in rivista Go to
2021 Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides Articolo in rivista Go to
2021 Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy Articolo in rivista Go to
2021 CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin Articolo in rivista Go to
2020 Inhibitors of antibiotic resistance mechanisms: clinical applications and future perspectives Articolo in rivista Go to
2020 Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry Capitolo o Saggio Go to
2020 Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells Articolo in rivista Go to
2020 Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance Articolo in rivista Go to
2020 Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds Articolo in rivista Go to
2020 New Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives Inhibit FAK Phosphorylation and Potentiate the Antiproliferative Effects of Gemcitabine Through Modulation of the Human Equilibrative Nucleoside Transporter-1 in Peritoneal Mesothelioma Articolo in rivista Go to
2020 Open Sesame? : Biomarker Status of the Human Equilibrative Nucleoside Transporter-1 and Molecular Mechanisms Influencing its Expression and Activity in the Uptake and Cytotoxicity of Gemcitabine in Pancreatic Cancer Articolo in rivista Go to
2020 3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1HIndole derivatives as new anticancer agents in the treatment of pancreatic ductal adenocarcinoma Articolo in rivista Go to
2019 Synthesis of novel 1,2,4-oxadiazole topsentin analogs with antitumor activity Contributo in atti di convegno pubblicato in volume Go to
2019 Biological evaluation of new 1,2,4-oxadiazole topsentin analogs as anticancer agents Abstract in atti di convegno pubblicato in volume Go to
2019 A Synthetic Derivative of Antimicrobial Peptide Holothuroidin 2 from Mediterranean Sea Cucumber (Holothuria tubulosa) in the Control of Listeria monocytogenes Articolo in rivista Go to
2019 Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines Articolo in rivista Go to
2019 2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors Articolo in rivista Go to
2019 Immunomodulatory activity of Humulus lupulus bitter acids fraction: Enhancement of natural killer cells function by NKp44 activating receptor stimulation Articolo in rivista Go to
2019 Quality, functional and sensory evaluation of pasta fortified with extracts from Opuntia ficus-indica cladodes Articolo in rivista Go to
2019 Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance Articolo in rivista Go to
2019 Pharmacogenetics of treatments for pancreatic cancer Articolo in rivista Go to
2019 Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives against Pancreatic Cancer Cells* Articolo in rivista Go to
2019 New 1,2,4-Oxadiazole Nortopsentin Derivatives with Cytotoxic Activity Articolo in rivista Go to
2018 An overview of recent molecular dynamics applications as medicinal chemistry tools for the undruggable site challenge Articolo in rivista Go to
2018 Proton-coupled folate transporter as a biomarker of outcome to treatment for pleural mesothelioma Articolo in rivista Go to
2018 Synthesis of 5H-pyrido[3,2-b]pyrrolizin-5-one tripentone analogs with antitumor activity Articolo in rivista Go to
2018 Polyphenolic Extract from Tarocco (Citrus sinensis L. Osbeck) Clone "Lempso" Exerts Anti-Inflammatory and Antioxidant Effects via NF-kB and Nrf-2 Activation in Murine Macrophages Articolo in rivista Go to
2018 Bacterial Biofilm Inhibition in the Development of Effective Anti-Virulence Strategy Articolo in rivista Go to
2018 New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation Articolo in rivista Go to
2018 A computational study to explore the molecular mechanisms behind the antiproliferative activity of Nortopsentin derivatives Proceedings Go to
2017 Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods Articolo in rivista Go to
2017 Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues Articolo in rivista Go to
2017 Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives Articolo in rivista Go to
2017 Pyrrolo[3′,2′:6,7]cyclohepta[1,2-b]pyridines with potent photo-antiproliferative activity Articolo in rivista Go to
2017 An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds Articolo in rivista Go to
2017 1,3,5-Triazines: A promising scaffold for anticancer drugs development Articolo in rivista Go to
2017 New Tripentone Analogs with Antiproliferative Activity Articolo in rivista Go to
2017 Pharmaceutical Approaches to Target Antibiotic Resistance Mechanisms Articolo in rivista Go to
2016 Synthesis and antiproliferative mechanism of action of pyrrolo[3′,2′:6,7] cyclohepta[1,2-d]pyrimidin-2-amines as singlet oxygen photosensitizers Articolo in rivista Go to
2016 Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma Articolo in rivista Go to
2016 [1,2]Oxazolo[5,4-e]isoindoles as promising tubulin polymerization inhibitors Articolo in rivista Go to
2016 Synthesis and antitumor activity of new 7-azaindole derivative nortopsentin analogues Abstract in atti di convegno pubblicato in volume Go to
2016 Design, synthesis and antiproliferative activity of pyrido-pyrido-pyrrolizines, new tripentone analogues Abstract in atti di convegno pubblicato in volume Go to
2016 Synthesis and antitumor activity of new thiazole nortopsentin analogs Articolo in rivista Go to
2016 Quality characteristics and in vitro digestibility study of barley flour enriched ditalini pasta Articolo in rivista Go to
2016 Pyrrolocycloheptaoxazole as potent antitumor agents Abstract in atti di convegno pubblicato in volume Go to
2015 3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin Analogues with antiproliferative activity Articolo in rivista Go to
2015 Pyrazolo[3,4-h]quinolines promising photosensitizing agents in the treatment of cancer Articolo in rivista Go to
2015 Quality characteristic and in vitro digestibility study of barley flour enriched ditalini pasta Proceedings Go to
2015 Aza-isoindolo and isoindolo-azaquinoxaline derivatives with antiproliferative activity Articolo in rivista Go to
2015 Synthesis and antiproliferative activity of thiazolyl-bis-pyrrolo[2,3-b]pyridines and indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, nortopsentin analogues Articolo in rivista Go to
2015 Synthesis and biological activity of a new series of nortopsentin analogues Proceedings Go to
2015 Nortopsentin analogues with potent activity against diffuse malignant peritoneal mesothelioma (DMPM) Proceedings Go to
2015 Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action Articolo in rivista Go to
2015 Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest Articolo in rivista Go to
2015 [1,2]oxazole[5,4-e]isoindoles as promising drugs for anticancer chemotherapy Proceedings Go to
2014 In vitro digestion of beta glucan enriched pasta: polysaccharide molecular characterization and antioxidant activity of bioaccessible fraction. Proceedings Go to
2014 ‘Interrupted’ diazotization of 3-aminoindoles and 3-aminopyrroles Articolo in rivista Go to
2014 Synthesis and biological evaluation of pyrrolo[3’,2’:6,7]cyclohepta[1,2-d]pyrimidin-2-amines Proceedings Go to
2014 Synthesis and antiproliferative activity of substituted 3[2-(1H-indol-3-yl)-1,3-thiazol-4-yl]-1H-pyrrolo[3,2-b]pyridines, marine alkaloid nortopsentin analogues Articolo in rivista Go to
2014 In vitro digestion of beta glucan enriched pasta and antioxidant potential of digesta Proceedings Go to
2014 SYNTHESYS AND ANTITUMOR ACTIVITY OF ISOINDOLO [2,1-A]QUINOXALIN-6-IMINES AND THEIR AZA-ANALOGUES Proceedings Go to
2014 Synthesis of substituted isoindolo[2,1-a]quinoxalin-6-yl–amino and 6-imino-5-yl thiourea derivatives Articolo in rivista Go to
2014 Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity Articolo in rivista Go to
2014 11H‑Pyrido[3′,2′:4,5]pyrrolo[3,2‑c]cinnoline and Pyrido[3′,2′:4,5]pyrrolo[1,2‑c][1,2,3]benzotriazine: Two New Ring Systems with Antitumor Activity Articolo in rivista Go to
2014 Synthesis of the New Ring System Bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and Its Deaza Analogue Articolo in rivista Go to
2013 Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents Articolo in rivista Go to
2013 Novel 1H‑Pyrrolo[2,3‑b]pyridine Derivative Nortopsentin Analogues: Synthesis and Antitumor Activity in Peritoneal Mesothelioma Experimental Models Articolo in rivista Go to
2013 2-substituted-[1,3]thiazolo[4,5-e]isoindoles as kinases inhibiting compounds Proceedings Go to
2013 Derivati di chinossalina, metodi per la loro produzione e loro uso come agenti antitumorali Brevetto Go to
2013 Synthesis of the new oligopeptide pyrrole derivative isonetropsin and its one pyrrole unit analogue Articolo in rivista Go to
2013 A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin Articolo in rivista Go to
2013 SYNTHESIS AND ANTITUMOR ACTIVITY IN PERITONEAL MESOTHELIOMA EXPERIMENTAL MODELS OF 1H-PIRROLO[2,3-b]PYRIDINE DERIVATIVES Proceedings Go to
2013 Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin Articolo in rivista Go to
2013 Convenient synthesis of pyrrolo[3,4-g]indazole Articolo in rivista Go to
2012 Synthesis and antitumor activity of new tetracyclic systems containing the pyrrole ring. Tesi di dottorato pre 2013 Go to
2012 3-[2-(1H-Indol-3-yl)-1,3-thiazol-4-yl)-1H-4-azaindole a new series of kinase inhibitors Proceedings Go to
2012 Synthesis of aza-isoindole quinoxalines with antitumor activity Proceedings Go to
2012 Antitumor activity of 2,5-bis-(3’-indolyl)-pyrroles, deaza-analogues of Nortopsentins Proceedings Go to
2012 Marine alkaloide analogues as kinase inhibitors Proceedings Go to
2012 An efficient synthesis of pyrrolo[3',2':4,5]thiopyrano[3,2-b]pyridin-2-one: a new ring system of pharmaceutical interest Articolo in rivista Go to
2012 Synthesis of pyrazolo[4,3-c][1,2,6]benzothiadiazocine,a new ring system as potential COX inhibitor Articolo in rivista Go to
2012 Synthesis and Antiproliferative Activity of the Ring System[1,2]Oxazolo[4,5-g]indole Articolo in rivista Go to
2012 New topoisomerase I inhibitors with condensed-azaindole structure Proceedings Go to
2011 Condensed azaindole with antitumor activity Proceedings Go to
2011 7-Azaindole-fused heterocycles with antitumor activity Proceedings Go to
2011 SYNTHESIS OF TETRACYCLIC SYSTEMS WITH POTENT ANTITUMOR ACTIVITY Proceedings Go to
2011 Synthesis of condensed quinoxalines with potent antitumor activity Proceedings Go to
2011 Synthesis of Triazenoazaindoles: a New Class of Triazenes with Antitumor Activity Articolo in rivista Go to
2011 Synthesis and Antitumor Activity of 3-(2-Phenyl-1,3-thiazol-4-yl)-1H-indoles and 3-(2-Phenyl-1,3-thiazol-4-yl)-1H-7-azaindoles Articolo in rivista Go to
2011 Synthesis of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one Articolo in rivista Go to
2010 SYNTHESIS AND ANTITUMOR ACTIVITY OF 3-[2-PHENYL-1,3-THIAZOL-4-YL]-1H-7-AZAINDOLES Proceedings Go to