| 2024 |
Triazole derivatives inhibit the VOR complex-mediated nuclear transport of extracellular particles: Potential application in cancer and HIV-1 infection |
Articolo in rivista |
Vai |
| 2024 |
Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: synthesis, mechanistic insights and promising antitumor and safety profile |
Articolo in rivista |
Vai |
| 2024 |
Novel [1,3,4]Thiadiazole[3,2-a]pyrimidin-5-ones as Promising Biofilm Dispersal Agents against Relevant Gram-Positive and Gram-Negative Pathogens |
Articolo in rivista |
Vai |
| 2024 |
Exploring the therapeutic potential of focal adhesion kinase inhibition in overcoming chemoresistance in pancreatic ductal adenocarcinoma |
Review essay (rassegna critica) |
Vai |
| 2023 |
Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy |
Articolo in rivista |
Vai |
| 2023 |
Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What is New? |
Articolo in rivista |
Vai |
| 2023 |
1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1 |
Articolo in rivista |
Vai |
| 2023 |
Discovery of the 3-Amino-1,2,4-triazine-Based Library as Selective PDK1 Inhibitors with Therapeutic Potential in Highly Aggressive Pancreatic Ductal Adenocarcinoma |
Articolo in rivista |
Vai |
| 2023 |
Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma |
Articolo in rivista |
Vai |
| 2023 |
A Combination of Polymethoxyflavones from Citrus sinensis and Prenylflavonoids from Humulus lupulus Counteracts IL-1β-Induced Differentiated Caco-2 Cells Dysfunction via a Modulation of NF-κB/Nrf2 Activation |
Articolo in rivista |
Vai |
| 2023 |
1,2,4-Amino-triazine derivatives as pyruvate dehydrogenase kinase inhibitors: Synthesis and pharmacological evaluation |
Articolo in rivista |
Vai |
| 2023 |
Nortopsentins as Leads from Marine Organisms for Anticancer and Anti-Inflammatory Agent Development |
Review essay (rassegna critica) |
Vai |
| 2022 |
Eight-Membered Rings With Two Heteroatoms 1,5 |
Capitolo o Saggio |
Vai |
| 2022 |
Eight-Membered Rings With Two Heteroatoms 1,3 |
Capitolo o Saggio |
Vai |
| 2022 |
Eight-membered heterocycles with two heteroatoms in a 1,3-relationship of interest in medicinal chemistry |
Capitolo o Saggio |
Vai |
| 2022 |
A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells |
Articolo in rivista |
Vai |
| 2022 |
Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification |
Articolo in rivista |
Vai |
| 2022 |
Eight-Membered Rings With Two Heteroatoms 1,2 |
Capitolo o Saggio |
Vai |
| 2021 |
1,2,4-Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase |
Articolo in rivista |
Vai |
| 2021 |
Dynamic-shared pharmacophore approach as tool to design new allosteric PRC2 inhibitors, targeting EED binding pocket |
Articolo in rivista |
Vai |
| 2021 |
Therapeutic strategies to counteract antibiotic resistance in MRSA biofilm-associated infections |
Review essay (rassegna critica) |
Vai |
| 2021 |
1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A |
Articolo in rivista |
Vai |
| 2021 |
CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin |
Articolo in rivista |
Vai |
| 2021 |
Eight-membered heterocycles with two heteroatoms in a 1,2-relationship of interest in medicinal chemistry |
Capitolo o Saggio |
Vai |
| 2021 |
SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance |
Articolo in rivista |
Vai |
| 2021 |
Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides |
Articolo in rivista |
Vai |
| 2021 |
Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy |
Articolo in rivista |
Vai |
| 2021 |
Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum |
Articolo in rivista |
Vai |
| 2021 |
Novel strategies in the war against antibiotic resistance |
Articolo in rivista |
Vai |
| 2021 |
Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation |
Articolo in rivista |
Vai |
| 2020 |
Inhibitors of antibiotic resistance mechanisms: clinical applications and future perspectives |
Articolo in rivista |
Vai |
| 2020 |
Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry |
Capitolo o Saggio |
Vai |
| 2020 |
Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells |
Articolo in rivista |
Vai |
| 2020 |
Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance |
Articolo in rivista |
Vai |
| 2020 |
New Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives Inhibit FAK Phosphorylation and Potentiate the Antiproliferative Effects of Gemcitabine Through Modulation of the Human Equilibrative Nucleoside Transporter-1 in Peritoneal Mesothelioma |
Articolo in rivista |
Vai |
| 2020 |
Open Sesame? : Biomarker Status of the Human Equilibrative Nucleoside Transporter-1 and Molecular Mechanisms Influencing its Expression and Activity
in the Uptake and Cytotoxicity of Gemcitabine in Pancreatic Cancer |
Articolo in rivista |
Vai |
| 2020 |
Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds |
Articolo in rivista |
Vai |
| 2020 |
3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1HIndole derivatives as new anticancer agents in the treatment of pancreatic ductal adenocarcinoma |
Articolo in rivista |
Vai |
| 2019 |
Synthesis of novel 1,2,4-oxadiazole topsentin analogs with antitumor activity |
Contributo in atti di convegno pubblicato in volume |
Vai |
| 2019 |
Biological evaluation of new 1,2,4-oxadiazole topsentin analogs as anticancer agents |
Abstract in atti di convegno pubblicato in volume |
Vai |
| 2019 |
Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines |
Articolo in rivista |
Vai |
| 2019 |
2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent staphylococcal biofilm inhibitors |
Articolo in rivista |
Vai |
| 2019 |
A Synthetic Derivative of Antimicrobial Peptide Holothuroidin 2 from Mediterranean Sea Cucumber (Holothuria tubulosa) in the Control of Listeria monocytogenes |
Articolo in rivista |
Vai |
| 2019 |
Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives against Pancreatic Cancer Cells* |
Articolo in rivista |
Vai |
| 2019 |
New 1,2,4-Oxadiazole Nortopsentin Derivatives with Cytotoxic Activity |
Articolo in rivista |
Vai |
| 2019 |
Quality, functional and sensory evaluation of pasta fortified with extracts from Opuntia ficus-indica cladodes |
Articolo in rivista |
Vai |
| 2019 |
Pharmacogenetics of treatments for pancreatic cancer |
Articolo in rivista |
Vai |
| 2019 |
Immunomodulatory activity of Humulus lupulus bitter acids fraction: Enhancement of natural killer cells function by NKp44 activating receptor stimulation |
Articolo in rivista |
Vai |
| 2019 |
Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance |
Articolo in rivista |
Vai |
| 2018 |
Proton-coupled folate transporter as a biomarker of outcome to treatment for pleural mesothelioma |
Articolo in rivista |
Vai |
| 2018 |
An overview of recent molecular dynamics applications as medicinal chemistry tools for the undruggable site challenge |
Articolo in rivista |
Vai |
| 2018 |
Synthesis of 5H-pyrido[3,2-b]pyrrolizin-5-one tripentone analogs with antitumor activity |
Articolo in rivista |
Vai |
| 2018 |
Bacterial Biofilm Inhibition in the Development of Effective Anti-Virulence Strategy |
Articolo in rivista |
Vai |
| 2018 |
New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation |
Articolo in rivista |
Vai |
| 2018 |
Polyphenolic Extract from Tarocco (Citrus sinensis L. Osbeck) Clone "Lempso" Exerts Anti-Inflammatory and Antioxidant Effects via NF-kB and Nrf-2 Activation in Murine Macrophages |
Articolo in rivista |
Vai |
| 2018 |
A computational study to explore the molecular mechanisms behind the antiproliferative activity of Nortopsentin derivatives |
Proceedings |
Vai |
| 2017 |
Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods |
Articolo in rivista |
Vai |
| 2017 |
Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues |
Articolo in rivista |
Vai |
| 2017 |
Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives |
Articolo in rivista |
Vai |
| 2017 |
Pyrrolo[3′,2′:6,7]cyclohepta[1,2-b]pyridines with potent photo-antiproliferative activity |
Articolo in rivista |
Vai |
| 2017 |
1,3,5-Triazines: A promising scaffold for anticancer drugs development |
Articolo in rivista |
Vai |
| 2017 |
An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds |
Articolo in rivista |
Vai |
| 2017 |
New Tripentone Analogs with Antiproliferative Activity |
Articolo in rivista |
Vai |
| 2017 |
Pharmaceutical Approaches to Target Antibiotic Resistance Mechanisms |
Articolo in rivista |
Vai |
| 2016 |
Synthesis and antiproliferative mechanism of action of pyrrolo[3′,2′:6,7] cyclohepta[1,2-d]pyrimidin-2-amines as singlet oxygen photosensitizers |
Articolo in rivista |
Vai |
| 2016 |
Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma |
Articolo in rivista |
Vai |
| 2016 |
[1,2]Oxazolo[5,4-e]isoindoles as promising tubulin polymerization inhibitors |
Articolo in rivista |
Vai |
| 2016 |
Synthesis and antitumor activity of new 7-azaindole derivative nortopsentin analogues |
Abstract in atti di convegno pubblicato in volume |
Vai |
| 2016 |
Design, synthesis and antiproliferative activity of pyrido-pyrido-pyrrolizines, new tripentone analogues |
Abstract in atti di convegno pubblicato in volume |
Vai |
| 2016 |
Synthesis and antitumor activity of new thiazole nortopsentin analogs |
Articolo in rivista |
Vai |
| 2016 |
Quality characteristics and in vitro digestibility study of barley flour enriched ditalini pasta |
Articolo in rivista |
Vai |
| 2016 |
Pyrrolocycloheptaoxazole as potent antitumor agents |
Abstract in atti di convegno pubblicato in volume |
Vai |
| 2015 |
3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin Analogues with antiproliferative activity |
Articolo in rivista |
Vai |
| 2015 |
Pyrazolo[3,4-h]quinolines promising photosensitizing agents in the treatment of cancer |
Articolo in rivista |
Vai |
| 2015 |
Quality characteristic and in vitro digestibility study of barley flour enriched ditalini pasta |
Proceedings |
Vai |
| 2015 |
Aza-isoindolo and isoindolo-azaquinoxaline derivatives with antiproliferative activity |
Articolo in rivista |
Vai |
| 2015 |
Synthesis and antiproliferative activity of thiazolyl-bis-pyrrolo[2,3-b]pyridines and indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, nortopsentin analogues |
Articolo in rivista |
Vai |
| 2015 |
Synthesis and biological activity of a new series of nortopsentin analogues |
Proceedings |
Vai |
| 2015 |
Nortopsentin analogues with potent activity against diffuse malignant peritoneal mesothelioma (DMPM) |
Proceedings |
Vai |
| 2015 |
Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest |
Articolo in rivista |
Vai |
| 2015 |
Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action |
Articolo in rivista |
Vai |
| 2015 |
[1,2]oxazole[5,4-e]isoindoles as promising drugs for anticancer chemotherapy |
Proceedings |
Vai |
| 2014 |
In vitro digestion of beta glucan enriched pasta and antioxidant potential of digesta |
Proceedings |
Vai |
| 2014 |
In vitro digestion of beta glucan enriched pasta: polysaccharide molecular characterization and antioxidant activity of bioaccessible fraction. |
Proceedings |
Vai |
| 2014 |
‘Interrupted’ diazotization of 3-aminoindoles and 3-aminopyrroles |
Articolo in rivista |
Vai |
| 2014 |
Synthesis and biological evaluation of pyrrolo[3’,2’:6,7]cyclohepta[1,2-d]pyrimidin-2-amines |
Proceedings |
Vai |
| 2014 |
11H‑Pyrido[3′,2′:4,5]pyrrolo[3,2‑c]cinnoline and Pyrido[3′,2′:4,5]pyrrolo[1,2‑c][1,2,3]benzotriazine: Two New Ring
Systems with Antitumor Activity |
Articolo in rivista |
Vai |
| 2014 |
Synthesis of the New Ring System Bispyrido[4',3':4,5]pyrrolo
[1,2-a:1',2'-d]pyrazine and Its Deaza Analogue |
Articolo in rivista |
Vai |
| 2014 |
SYNTHESYS AND ANTITUMOR ACTIVITY OF ISOINDOLO [2,1-A]QUINOXALIN-6-IMINES AND THEIR AZA-ANALOGUES |
Proceedings |
Vai |
| 2014 |
Synthesis of substituted isoindolo[2,1-a]quinoxalin-6-yl–amino and
6-imino-5-yl thiourea derivatives |
Articolo in rivista |
Vai |
| 2014 |
Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic
activity |
Articolo in rivista |
Vai |
| 2014 |
Synthesis and antiproliferative activity of substituted 3[2-(1H-indol-3-yl)-1,3-thiazol-4-yl]-1H-pyrrolo[3,2-b]pyridines, marine alkaloid nortopsentin analogues |
Articolo in rivista |
Vai |
| 2013 |
Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents |
Articolo in rivista |
Vai |
| 2013 |
Novel 1H‑Pyrrolo[2,3‑b]pyridine Derivative Nortopsentin Analogues:
Synthesis and Antitumor Activity in Peritoneal Mesothelioma
Experimental Models |
Articolo in rivista |
Vai |
| 2013 |
2-substituted-[1,3]thiazolo[4,5-e]isoindoles as kinases inhibiting compounds |
Proceedings |
Vai |
| 2013 |
Derivati di chinossalina, metodi per la loro produzione e loro uso come agenti antitumorali |
Brevetto |
Vai |
| 2013 |
Synthesis of the new oligopeptide pyrrole derivative isonetropsin
and its one pyrrole unit analogue |
Articolo in rivista |
Vai |
| 2013 |
A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin |
Articolo in rivista |
Vai |
| 2013 |
SYNTHESIS AND ANTITUMOR ACTIVITY IN PERITONEAL MESOTHELIOMA EXPERIMENTAL MODELS OF 1H-PIRROLO[2,3-b]PYRIDINE DERIVATIVES |
Proceedings |
Vai |
| 2013 |
Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin |
Articolo in rivista |
Vai |
| 2013 |
Convenient synthesis of pyrrolo[3,4-g]indazole |
Articolo in rivista |
Vai |
| 2012 |
Marine alkaloide analogues as kinase inhibitors |
Proceedings |
Vai |
| 2012 |
Synthesis and antitumor activity of new tetracyclic systems containing the pyrrole ring. |
Tesi di dottorato pre 2013 |
Vai |
| 2012 |
3-[2-(1H-Indol-3-yl)-1,3-thiazol-4-yl)-1H-4-azaindole a new series of kinase inhibitors |
Proceedings |
Vai |
| 2012 |
Synthesis of aza-isoindole quinoxalines with antitumor activity |
Proceedings |
Vai |
| 2012 |
Synthesis and Antiproliferative Activity of the Ring System[1,2]Oxazolo[4,5-g]indole |
Articolo in rivista |
Vai |
| 2012 |
New topoisomerase I inhibitors with condensed-azaindole structure |
Proceedings |
Vai |
| 2012 |
An efficient synthesis of pyrrolo[3',2':4,5]thiopyrano[3,2-b]pyridin-2-one:
a new ring system of pharmaceutical interest |
Articolo in rivista |
Vai |
| 2012 |
Synthesis of pyrazolo[4,3-c][1,2,6]benzothiadiazocine,a new ring system as potential COX inhibitor |
Articolo in rivista |
Vai |
| 2012 |
Antitumor activity of 2,5-bis-(3’-indolyl)-pyrroles, deaza-analogues of Nortopsentins |
Proceedings |
Vai |
| 2011 |
7-Azaindole-fused heterocycles with antitumor activity |
Proceedings |
Vai |
| 2011 |
Condensed azaindole with antitumor activity |
Proceedings |
Vai |
| 2011 |
SYNTHESIS OF TETRACYCLIC SYSTEMS WITH POTENT ANTITUMOR ACTIVITY |
Proceedings |
Vai |
| 2011 |
Synthesis of condensed quinoxalines with potent antitumor activity |
Proceedings |
Vai |
| 2011 |
Synthesis of Triazenoazaindoles: a New Class of Triazenes with Antitumor Activity |
Articolo in rivista |
Vai |
| 2011 |
Synthesis and Antitumor Activity of 3-(2-Phenyl-1,3-thiazol-4-yl)-1H-indoles and 3-(2-Phenyl-1,3-thiazol-4-yl)-1H-7-azaindoles |
Articolo in rivista |
Vai |
| 2011 |
Synthesis of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one |
Articolo in rivista |
Vai |
| 2010 |
SYNTHESIS AND ANTITUMOR ACTIVITY OF 3-[2-PHENYL-1,3-THIAZOL-4-YL]-1H-7-AZAINDOLES |
Proceedings |
Vai |
