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ANNAMARIA MARTORANA

Curriculum and Research

MARTORANA ANNAMARIA

ANNAMARIA MARTORANA

 (CHEM-07/A)

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Contacts

+3909123896821

annamaria.martorana@unipa.it

Download the curriculum in pdf file

Subjects

Academic Year Subject identification code Subject name ECTS Course of study
2024/2025 19175 ANALISI DEI MEDICINALI E DI BIOMOLECOLE 8 FARMACIA

Publications

Date Title Type Record
2024 Bioisosteric heterocyclic analogues of natural bioactive flavonoids by scaffold-hopping approaches: State-of-the-art and perspectives in medicinal chemistry Review essay (rassegna critica) Go to
2024 Scaffold-Hopping Strategies in Aurone Optimization: A Comprehensive Review of Synthetic Procedures and Biological Activities of Nitrogen and Sulfur Analogues Review essay (rassegna critica) Go to
2024 New small molecules for the Treatment of TNBC innovative Polypharmacological In Silico Approach Abstract in atti di convegno pubblicato in volume Go to
2023 In Silico Design of New Dual Inhibitors of SARS-CoV-2 MPRO through Ligand- and Structure-Based Methods Articolo in rivista Go to
2023 In silico lead optimization and synthesis of a new series of thieno[3,2-c]quinoline with antiproliferative activity on RET-dependent medullary thyroid cancer cells Abstract in atti di convegno pubblicato in volume Go to
2023 Synthesis of new antiproliferative 1,3,4-substituted-pyrrolo[3,2-c]quinoline derivatives, biological and in silico insights Articolo in rivista Go to
2023 In Silico Mixed Ligand/Structure-Based Design of New CDK-1/PARP-1 Dual Inhibitors as Anti-Breast Cancer Agents Articolo in rivista Go to
2023 Design and Synthesis of Novel Thieno[3,2-c]quinoline Compounds with Antiproliferative Activity on RET-Dependent Medullary Thyroid Cancer Cells Articolo in rivista Go to
2022 Targeting SARS-CoV-2 Main Protease for Treatment of COVID-19: Covalent Inhibitors Structure-Activity Relationship Insights and Evolution Perspectives Articolo in rivista Go to
2022 Antiproliferative Activity Predictor: A New Reliable In Silico Tool for Drug Response Prediction against NCI60 Panel Articolo in rivista Go to
2022 Antiproliferative Activity Predictor: un nuovo tool in silico per predire l’attività antiproliferativa nei confronti del pannello NCI60 Abstract in atti di convegno pubblicato in volume Go to
2022 One pot-like regiospecific access to 1-aryl-1H-pyrazol-3(2H)-one derivatives and evaluation of the anticancer activity Articolo in rivista Go to
2021 Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets Articolo in rivista Go to
2021 Identification of biological targets through the correlation between cell line chemosensitivity and protein expression pattern Review essay (rassegna critica) Go to
2021 Antiproliferative properties and g-quadruplex-binding of symmetrical naphtho[1,2-b:8,7-b’]dithiophene derivatives Articolo in rivista Go to
2021 In silico identification of small molecules as new cdc25 inhibitors through the correlation between chemosensitivity and protein expression pattern Articolo in rivista Go to
2021 Off-target-based design of selective hiv-1 protease inhibitors Articolo in rivista Go to
2020 Design of antitumor drugs targeting c-kit receptor by a new mixed ligand-structure based method Articolo in rivista Go to
2020 Identification of an LPS-induced chemo-attractive peptide from ciona robusta Articolo in rivista Go to
2020 In Silico Insights into the SARS CoV-2 Main Protease Suggest NADH Endogenous Defences in the Control of the Pandemic Coronavirus Infection Articolo in rivista Go to
2020 Quinoline-based molecules targeting c-Met, EGF, and VEGF receptors and the proteins involved in related carcinogenic pathways Articolo in rivista Go to
2020 Synthesis, biological evaluation, and: In silico studies of novel chalcone: In pyrazoline-based 1,3,5-triazines as potential anticancer agents Articolo in rivista Go to
2020 DRUDIT: Web-based DRUgs DIscovery Tools to design small molecules as modulators of biological targets Articolo in rivista Go to
2018 New insights into the mechanism of action of pyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-one derivatives endowed with anticancer potential Articolo in rivista Go to
2018 Design, synthesis, and biological evaluation of a new class of benzo[b]furan derivatives as antiproliferative agents, with in silico predicted antitubulin activity Articolo in rivista Go to
2017 Kinase Inhibitors in Multitargeted Cancer Therapy Articolo in rivista Go to
2017 Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns Articolo in rivista Go to
2016 G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes Articolo in rivista Go to
2016 Drugs Polypharmacology by In Silico Methods: New Opportunities in Drug Discovery Articolo in rivista Go to
2016 The Repurposing of Old Drugs or Unsuccessful Lead Compounds by in Silico Approaches: New Advances and Perspectives Articolo in rivista Go to
2016 Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease Articolo in rivista Go to
2015 Selective in vitro antileukemic activity (HL-60, K-562, MOLT-4, SR) of new chloro-propyl-pyrazolo[1,2-a]benzo[1,2,5]triazepinones Poster pubblicato in volume Go to
2015 Ni(II) and Zn(II) Schiff Base complexes: B-DNA vs G4-DNA binding Abstract in atti di convegno pubblicato in volume Go to
2015 Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[ b ]thiophene derivatives Articolo in rivista Go to
2014 New benzothieno[3,2-d]-1,2,3-triazines with antiproliferative activity: Synthesis, spectroscopic studies, and biological activity Articolo in rivista Go to
2014 NiII, and ZnII Schiff Base Complexes: Telomeric G-quadruplex Stabilizers Proceedings Go to
2014 Selective G-Quadruplex Stabilizers: Schiff-base Metal Complexes with Anticancer Activity Articolo in rivista Go to
2014 The Interaction of Small Molecules with Biomolecules Proceedings Go to
2014 Does ligand symmetry play a role in the stabilization of DNA g-quadruplex host-guest complexes? Articolo in rivista Go to
2014 In silico, spectroscopic, and biological insights on annelated pyrrolo[3,2-e]pyrimidines with antiproliferative activity Articolo in rivista Go to
2014 Double chained naphthalenes as G4 binders Proceedings Go to
2014 1,2,3-Triazole in Heterocyclic Compounds, Endowed with Biological Activity, through 1,3-Dipolar Cycloadditions Articolo in rivista Go to
2013 An Unexpected Dimroth Rearrangement Leading to Annelated Thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidines with Potent Antitumor Activity Articolo in rivista Go to
2013 Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening Articolo in rivista Go to
2013 New annelated thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines, with potent anticancer activity, designed through VLAK protocol Articolo in rivista Go to
2013 Hsp60, a novel target for antitumor therapy: Structure-function features and prospective drugs design Articolo in rivista Go to
2013 SYNTHESIS AND EVALUATION OF CURCUMIN ANALOGUES AS NEURO-PROTECTIVE AGENTS FOR THE ALZHEIMER'S DISEASE Proceedings Go to
2013 SELECTIVE G-QUADRUPLEX STABILIZERS: SALPHEN-LIKE COMPLEXES WITH ANTIPROLIFERATIVE ACTIVITY Proceedings Go to
2013 Exploring the anticancer potential of pyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-one derivatives: The effect on apoptosis induction, cell cycle and proliferation Articolo in rivista Go to
2013 Design and synthesis of high affinity compounds for the Hsp60 expression control in carcinogenic processes Proceedings Go to
2013 Verso l’ottimizzazione dell’attività antiproliferativa di derivati pirroloisochinolinici Proceedings Go to
2012 Antiproliferative activity of Pyrrolo[3,2-c]quinoline derivatives Proceedings Go to
2012 Pharmacophore modelling as useful tool in the lead compounds identification and optimization Proceedings Go to
2012 DERIVATI TIENO[3,2-d]-1,2,3-TRIAZIN-4(3H)ONI ANELLATI:UNA NUOVA CLASSE DI INIBITORI DI AURORA CHINASI A Proceedings Go to
2012 Synthesis, characterization and DNA binding studies of potential G4 stabilizer metal complexes Proceedings Go to
2012 NOVEL ANTAGONISTS FOR AN Hsp60-BASED ANTICANCER CHAPERONOTHERAPY Proceedings Go to
2012 1,2-Dihydropyrazole[1,2-a]benzo[1,2,4]triazine-3-one: deaza analogue tricyclic scaffold with valuable antiproliferative activity Proceedings Go to
2012 Lead optimization through VLAK protocol: New annelated pyrrolo-pyrimidine derivatives as antitumor agents Articolo in rivista Go to
2012 Synthesis of Tetrasubstituted 4,4'-Biimidazoles Articolo in rivista Go to
2012 Synthesis of tetrasubstituted-4,4'-biimidazoles with perspective heavy-metal sensing ability Proceedings Go to
2011 Synthesis and antiproliferative activity of Naphtalenyl substituted 1,2-dihydropyrazol-5-one and related fused tetrazine Proceedings Go to
2011 Synthesis of 4(5)-phenacyl-imidazoles from isoxazole side-chain rearrangements Articolo in rivista Go to
2011 Nucleophilic substitutions in the isoindole series as a valuable tool to synthesize derivatives with antitumor activity Articolo in rivista Go to
2011 Nuovi inibitori di Aurora chinasi A come target biologico coinvolto nei processi carcinogenici Proceedings Go to
2010 Uncatalyzed photofunctionalization of C-H bonds Proceedings Go to
2010 SINTESI DI IMIDAZOLI E 4,4’-BISIMIDAZOLI FUNZIONALIZZATI, TRAMITE REAZIONI DI RIARRANGIAMENTO DI ISOSSAZOLI Proceedings Go to
2010 Sintesi di nuovi low molecular weight (LMW) hydrogelators fluorurati Proceedings Go to
2009 Pyrido[4′,3′:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazines, a new class of Temozolomide heteroanalogues Articolo in rivista Go to
2009 Pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a new class of temozolomide heteroanalogues Articolo in rivista Go to
2009 NUCLEOPHILIC SUBSTITUTIONS IN ISOINDOLE SERIES AS VALUABLE TOOL TO SYNTHESIZE DERIVATIVES WITH ANTITUMOR ACTIVITY Proceedings Go to
2009 Synthesis of the New Ring System 2-Oxo-[1,4]oxazino[3,2-e]indole, Heteroanalogue of Angelicin Articolo in rivista Go to
2009 PYRROLO[3',2':4,5]THIOPYRANO[3,2-b]PYRIDIN-2-ONES WITH POTENTIAL ANTITUMOR ACTIVITY Proceedings Go to
2009 3-[2-(1H-Indol-3-yl)-1,3-thiazol-4-yl)-1H-pyrrolo[3,2-b]pyridine: a new series of kinase inhibitors Proceedings Go to
2008 BIS-INDOLYL-5-MEMBER HETEROCYCLES ANALOGUES OF MARINE ALKALOID NORTOPSENTIN: SYNTHESES AND ANTINEOPLASTIC ACTIVITY Proceedings Go to
2008 SYNTHESIS OF 3-(2-PHENYL-1,3-THIAZOL-4-YL)-1H-INDOLES, NEW DERIVATIVES WITH POTENTIAL ANTINEOPLASTIC ACTIVITY Proceedings Go to
2008 ISOINDOLO[2,1-a]QUINOXALINE DERIVATIVES, NOVEL POTENT ANTITUMOR AGENTS WITH DUAL INHIBITION OF TUBULIN POLYMERIZATION AND TOPOISOMERASE I Articolo in rivista Go to
2007 SINTESI DI NUOVI DERIVATI[2,3-E]ISOINDOL-2-ONI A POTENZIALE ATTIVITA' FOTOCHEMIOTERAPICA Proceedings Go to
2007 Synthesis and Antitumor Properties of 2,5-Bis(3'-indolyl) thiophenes: Analogues of Marine Alkaloid Nortopsentin Articolo in rivista Go to
2007 Nanostructured Lipid Carriers-Containing Anticancer Compounds: Preparation, Characterization, and Cytotoxicity Studies Articolo in rivista Go to
2007 PYRROLO[3,4-G]INDAZOLE A NEW RING SYSTEM WITH POTENTIAL ANTITUMOR ACTIVITY Proceedings Go to
2007 5H-Pirido[3’,2’:4,5]Pirrolo[3,2-c]Cinnolina un Nuovo Sistema Eterociclico a Potenziale Attività Antitumorale Proceedings Go to
2007 SINTESI DI 2,5-BIS[3-(7-AZAINDOLIL)]TIOFENI ANALOGHI DELLA NORTOPSENTINA Proceedings Go to
2007 SINTESI ED ATTIVITÀ ANTITUMORALE DI ANALOGHI PENTATOMICI DELLA NORTOPSENTINA Proceedings Go to
2007 7-AZAINDOLO[1,2-c][1,2,3]BENZOTRIAZINA UN NUOVO SISTEMA ETEROCICLICO A POTENZIALE ATTIVITA’ ANTITUMORALE Proceedings Go to
2007 3,5-BIS(3’-INDOLYL)PYRAZOLES, ANALOGUES OF MARINE ALKALOID NORTOPSENTIN: SYNTHESIS AND ANTITUMOR PROPERTIES Articolo in rivista Go to
2007 4-AZA E 7-AZA-ISOINDOLO[1,2-a]CHINOSSALINE: DUE NUOVI SISTEMI ETEROCICLICI A POTENZIALE ATTIVITÀ ANTITUMORALE Proceedings Go to
2007 ISOINDOLO[2,1-C]BENZO[1,2,4]TRIAZINES: A NEW RING SYSTEM WITH ANTIPROLIFERATIVE ACTIVITY Articolo in rivista Go to
2007 SYNTHESIS OF 3,5-BIS(3'-INDOLYL)ISOXAZOLES, ANALOGUES OF MARINE ALKALOID NORTOPSENTIN Proceedings Go to
2007 SYNTHESIS OF PYRROLO[3,4-H]QUINAZOLIN-2-ONE A NEW RING SYSTEM WITH POTENTIAL PHOTOTHERAPEUTIC ACTIVITY Proceedings Go to
2006 Sintesi ed Attività Antitumorale di Bis(indolil)eterocicli: Analoghi dell’Alcaloide Marino Nortopsentina Proceedings Go to
2006 SYNTHESIS OF 2,5-BIS(3'-INDOLYL)-FURANS, ANALOGUES OF NORTOPSENTIN Proceedings Go to
2006 SINTESI DELL'ISONETROPSINA E DELL'ISOMERO DIMERICO DELLA DISTAMICIA A Proceedings Go to
2006 PYRANO[2,3-E]ISOINDOL-2-ONE: A NEW RING SYSTEM WITH POTENTIAL PHOTOBIOLOGICAL PROPERTIES Proceedings Go to
2006 Sintesi del Nuovo Sistema Eterociclico 7-Azaindolocinnolinico come Potenziale Agente Antineoplastico Proceedings Go to
2006 SYNTHESIS OF 2,5-BIS(3'-INDOLYL)-PYRROLES, DEAZA-ANALOGUES OF NORTOPSENTIN Proceedings Go to
2005 SYNTHESIS, REACTIVITY AND ANTINEOPLASTIC ACTIVITY OF ISOINDOLE DERIVATIVES Proceedings Go to
2005 NOVEL OXIDATION PRODUCTS OF ANTITUMOR AZOLES Proceedings Go to
2005 Isoindolo[1,2-a]quinoxaline derivatives with potent antitumor activity. Proceedings Go to
2004 SINTESI DI SISTEMI POLICICLICI CONTENENTI IL NUCLEO ISOINDOLICO AD ATTIVITA' ANTITUMORALE Proceedings Go to
2004 SYNTHESIS, REACTIVITY OF ISOINDOLE DERIVATIVES Proceedings Go to
2004 Studi di Molecular Modelling su Derivati del Nuovo Sistema Eterociclico DNA-interattivo Isoindolo[2,1-c]benzo[1,2,4]triazina Proceedings Go to