Co-deposition and characterization of hydroxyapatite-chitosan and hydroxyapatite-polyvinylacetate coatings on 304 SS for biomedical devices

Abstract

During the last decades, biomaterials have been deeply studied to fabricate and improve coatings for biomedical devices. Metallic materials, especially in the orthopedic field, represent the most common materials used for different type of devices thanks to their good mechanical properties. Nevertheless, low/medium resistance to corrosion and low osteointegration ability characterizes these materials. To overcome these problems, the use of biocoatings on metals substrate is largely diffused. In fact, biocoatings have a key role to confer biocompatibility features, to inhibit corrosion and thus improve the lifetime of implanted devices. In this work, the attention was focused on Hydroxyapatite-Chitosan (HA/CS) and Hydroxyapatite-Polyvinylacetate (HA/PVAc) composites, that have been studied as biocoatings for 304 SS based devices. Hydroxyapatite was selected for its osteoconductivity due to its chemical structure similar to bones. Furthermore, Chitosan and Polyvinylacetate are largely used yet in medical field (e.g. antibacterial agent or drug deliver) and in this work were used to create a synergic interaction with hydroxyapatite to increase the strength and bioactivity of coating. Despite bio-coatings were obtained by different techniques, in this work, they were fabricated by galvanic deposition process that has different advantages, among which it does not require external power supply. It is a spontaneous electrochemical reaction in which materials with different standard electrochemical potential were short-circuited and immersed in an electrolytic solution. Electrons supplied by the anodic reaction at the less noble electrode flow to cathode where they oxidize the less noblest ions in solution. SEM, EDS, XRD and RAMAN were performed for chemical-physics characterization of biocoatings. Polarization and impedance measurements have been also carried out to evaluate corrosion behavior. Besides, in-vitro cytotoxicity assays have been done for the biological features.