TISSUE ENGINEERING FOR THE DEVELOPMENT OF THREE-DIMENSIONAL INVITRO MODELS OF HUMAN MUCOSAE

Abstract

Traditional two-dimensional (2D) cell cultures only partially reflect the morpho-molecular pattern of human cells in tissues, and they are also unable to fully mimic the complexity of the in vivo microenvironment. Cell development in in vivo systems differs significantly from classical 2D cell culture models, especially with regard to the morphology, growth kinetics, gene expression and the degree of differentiation. Tissue engineering allows the reproduction of tissues by cell seeding on biocompatible scaffolds, to form a homogenous ...