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GIULIO GHERSI

Curriculum and Research

Subjects

Academic Year Subject identification code Subject name ECTS Course of study
2024/2025 01542 BIOCHIMICA 12 BIOTECNOLOGIE
2024/2025 01548 BIOCHIMICA APPLICATA (MODULO) 6 BIOTECNOLOGIE INDUSTRIALI BIOMOLECOLARI
2024/2025 01551 BIOCHIMICA APPLICATA C.I. 9 BIOTECNOLOGIE INDUSTRIALI BIOMOLECOLARI

Publications

Date Title Type Record
2024 Effects of Cerebrospinal Fluids from Alzheimer and Non-Alzheimer Patients on Neurons–Astrocytes–Microglia Co-Culture Articolo in rivista Go to
2024 An Airlift Perfusion Bioreactor for Tissue Engineering Applications: from Computational Modeling to Experimental Validation Articolo in rivista Go to
2024 Improvement of Osteogenic Differentiation of Mouse Pre-Osteoblastic MC3T3-E1 Cells on Core–Shell Polylactic Acid/Chitosan Electrospun Scaffolds for Bone Defect Repair Articolo in rivista Go to
2023 Microglial Activation and Priming in Alzheimer’s Disease: State of the Art and Future Perspectives Review essay (rassegna critica) Go to
2023 Computational modeling and experimental characterization of fluid dynamics in micro-CT scanned scaffolds within a multiple-sample airlift perfusion bioreactor Articolo in rivista Go to
2023 Mimicking Molecular Pathways in the Design of Smart Hydrogels for the Design of Vascularized Engineered Tissues Review essay (rassegna critica) Go to
2023 Cerebrospinal and Blood Biomarkers in Alzheimer's Disease: Did Mild Cognitive Impairment Definition Affect Their Clinical Usefulness? Review essay (rassegna critica) Go to
2023 Recovery of Bioactive Compounds from Marine Organisms: Focus on the Future Perspectives for Pharmacological, Biomedical and Regenerative Medicine Applications of Marine Collagen Review essay (rassegna critica) Go to
2023 The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases Review essay (rassegna critica) Go to
2023 Microglial Activation and Priming in Alzheimer’s Disease: State of the Art and Future Perspectives Review essay (rassegna critica) Go to
2023 CX3CL1 Pathway as a Molecular Target for Treatment Strategies in Alzheimer’s Disease Review essay (rassegna critica) Go to
2023 Nanoformulations based on collagenases loaded into halloysite/Veegum® clay minerals for potential pharmaceutical applications Articolo in rivista Go to
2022 Recent developments and applications of smart nanoparticles in biomedicine Review essay (rassegna critica) Go to
2022 Mathematical and numerical modeling of an airlift perfusion bioreactor for tissue engineering applications Articolo in rivista Go to
2022 Continuous Microfiber Wire Mandrel-Less Biofabrication for Soft Tissue Engineering Applications. Articolo in rivista Go to
2022 Fed-batch pre-industrial production and purification of a consensus tetratricopeptide repeat (CTPR) scaffold as a container for Fluorescent Proteins (FPs) Articolo in rivista Go to
2022 Radiation-tailored xyloglucan-doxorubicin nanoparticles for cancer therapy Abstract in atti di convegno pubblicato in volume Go to
2021 Additive Manufacturing of Multi-Scale Porous Soft Tissue Implants That Encourage Vascularization and Tissue Ingrowth Articolo in rivista Go to
2021 Assessing the effects of VEGF releasing microspheres on the angiogenic and foreign body response to a 3D printed silicone-based macroencapsulation device Articolo in rivista Go to
2021 The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model Articolo in rivista Go to
2021 3d collagen hydrogel promotes in vitro langerhans islets vascularization through ad-mvfs angiogenic activity Articolo in rivista Go to
2021 Functionalized poly(N-isopropylacrylamide)-based microgels in tumor targeting and drug delivery Articolo in rivista Go to
2021 Physical and biological properties of electrospun poly(d,l-lactide)/nanoclay and poly(d,l-lactide)/nanosilica nanofibrous scaffold for bone tissue engineering Articolo in rivista Go to
2021 Tuning of the Mg Alloy AZ31 Anodizing Process for Biodegradable Implants Articolo in rivista Go to
2021 Galvanic deposition of Hydroxyapatite/Chitosan/Collagen coatings on 304 stainless steel Articolo in rivista Go to
2021 Core-shell PLA/Kef hybrid scaffolds for skin tissue engineering applications prepared by direct kefiran coating on PLA electrospun fibers optimized via air-plasma treatment Articolo in rivista Go to
2021 Galvanic Deposition of Hydroxyapatite/Chitosan/Collagen Coatings on 304 Stainless Steel Contributo in atti di convegno pubblicato in volume Go to
2021 Effect of E. coli biofilm formation and removal on passive films on AISI 316L during fermentation processes Articolo in rivista Go to
2020 Development of injectable and durable kefiran hydro-alcoholic gels Articolo in rivista Go to
2020 Production of Injectable Marine Collagen-Based Hydrogel for the Maintenance of Differentiated Chondrocytes in Tissue Engineering Applications Articolo in rivista Go to
2020 Neural Crest-Derived Chondrocytes Isolation for Tissue Engineering in Regenerative Medicine Articolo in rivista Go to
2019 Deposition and characterization of Hydroxyapatite-Chitosan coatings on 304 SS for biomedical devices Proceedings Go to
2019 A 3D‑scaffold of PLLA induces the morphological differentiation and migration of primary astrocytes and promotes the production of extracellular vesicles Articolo in rivista Go to
2019 Microscopic evidence of the primary astrocytes' morphological differentiation and migration inside porous Poly-L-lactic acid 3D‑scaffolds Abstract in atti di convegno pubblicato in volume Go to
2019 Vascular Endothelial Growth Factor-Releasing Microspheres Based on Poly(ε-Caprolactone-PEG-ε-Caprolactone)-b-Poly(L-Lactide) Multiblock Copolymers Incorporated in a Three-Dimensional Printed Poly(Dimethylsiloxane) Cell Macroencapsulation Device Articolo in rivista Go to
2019 Vibrio proteases for biomedical applications: Modulating the proteolytic secretome of v. alginolyticus and v. parahaemolyticus for improved enzymes production Articolo in rivista Go to
2019 PLLA scaffolds with controlled architecture as potential microenvironment for in vitro tumor model Articolo in rivista Go to
2019 Co-deposition and characterization of hydroxyapatite-chitosan and hydroxyapatite-polyvinylacetate coatings on 304 SS for biomedical devices Contributo in atti di convegno pubblicato in volume Go to
2018 Graphene nanosystems as supports in siRNA Delivery Articolo in rivista Go to
2018 Isolation of adult rat cardiomyocytes using recombinant collagenases Articolo in rivista Go to
2018 Preparation, characterization and in vitro test of composites poly-lactic acid/hydroxyapatite scaffolds for bone tissue engineering Articolo in rivista Go to
2017 E-beam crosslinked nanogels conjugated with monoclonal antibodies in targeting strategies Articolo in rivista Go to
2017 Electrospun PCL/GO-g-PEG structures: Processing-morphology-properties relationships Articolo in rivista Go to
2017 Functionalization of nanoparticles in specific targeting and mechanism release Capitolo o Saggio Go to
2017 Novel inulin-based mucoadhesive micelles loaded with corticosteroids as potential transcorneal permeation enhancers Articolo in rivista Go to
2017 Physico-chemical and mechanical characterization of in-situ forming xyloglucan gels incorporating a growth factor to promote cartilage reconstruction Articolo in rivista Go to
2017 A poly-L-lactic acid/ collagen/glycosaminoglycan matrix for tissue engineering applications Articolo in rivista Go to
2017 Double flow bioreactor for in vitro test of drug delivery Articolo in rivista Go to
2017 Bi-layer PCL/PLA scaffold prepared by melt for interface tissue engineering Abstract non pubblicato Go to
2017 Engineering approaches in siRNA delivery Articolo in rivista Go to
2016 Sterilization of macroscopic poly(l-lactic acid) porous scaffolds withdense carbon dioxide: Investigation of the spatial penetration of thetreatment and of its effect on the properties of the matrix Articolo in rivista Go to
2016 Preparation of three-layered porous PLA/PEG scaffold: Relationship between morphology, mechanical behavior and cell permeability Articolo in rivista Go to
2016 Integration of PCL and PLA in a monolithic porous scaffold for interface tissue engineering Articolo in rivista Go to
2016 Melt Processed PCL/PEG Scaffold with Discrete Pore Size Gradient for Selective Cellular Infiltration Articolo in rivista Go to
2016 Multi-functional nanogels for tumor targeting and redox-sensitive drug and siRNA delivery Articolo in rivista Go to
2016 Proteolytic Enzymes Clustered in Specialized Plasma-Membrane Domains Drive Endothelial Cells' Migration Articolo in rivista Go to
2016 PLLA Scaffold via TIPS for Bone Tissue Engineering Articolo in rivista Go to
2016 Double Flow Bioreactor for In Vitro Test of Drug Delivery Proceedings Go to
2016 Mucoadhesive micelles based on inulin derivative for ocular release of corticosteroids Abstract in atti di convegno pubblicato in volume Go to
2016 Polyaminoacid–doxorubicin prodrug micelles as highly selective therapeutics for targeted cancer therapy Articolo in rivista Go to
2015 Self-organized environment-sensitive inulin-doxorubicin conjugate with a selective cytotoxic effect towards cancer cells Articolo in rivista Go to
2015 Radiation engineered nanogels as platforms for medical diagnostics and therapeutic nanodevices Capitolo o Saggio Go to
2015 Comprehensive analysis of a Vibrio parahaemolyticus strain extracellular serine protease VpSP37 Articolo in rivista Go to
2015 PHEA-Dox nanoparticles as pH-sensitive model for drug delivery in tumour treatment. Proceedings Go to
2014 Supercritical carbon dioxide induces sterilization of PLLA scaffolds contaminated by E. coli. Proceedings Go to
2014 Water-borne e-beam crosslinked nanogels as nanomaterials platform for drug delivery Proceedings Go to
2014 Pore size graded scaffold for selective cellular permeation Proceedings Go to
2014 Oligonucleotides-decorated-poly(N-vinyl pyrrolidone) nanogels for gene delivery Articolo in rivista Go to
2014 3D collagen matrix improves islets of Langerhans differentiation and function Proceedings Go to
2014 Use of recombinant collagenases class I and II in optimization of cell purification for tissue engineering applications Proceedings Go to
2014 Tissue Dissociation and Primary Cells Isolation Using Recombinant Collagenases Class I and II Proceedings Go to
2014 FOLATE-DECORATED E-BEAM CROSSLINKED NANOGELS TO ENHANCE UPTAKE BY TUMOR CELLS Proceedings Go to
2014 E-Beam Crosslinked Polymeric and Bio-Hybrid Nanocarriers for Drug Delivery and Bioimaging Proceedings Go to
2014 Biocompatibility evaluation of PLLA scaffolds for vascular tissue engineering Proceedings Go to
2014 Formulation of Different Chitosan Hydrogels for Cartilage Tissue Repair Proceedings Go to
2014 Scaffold con gradiente della dimensione dei pori per la migrazione selettiva di cellule eterotipiche Proceedings Go to
2014 PLLA/Fibrin Tubular Scaffold: A New Way for Reliable Endothelial Cell Seeding Proceedings Go to
2014 Glutathione-sensitive nanogels for drug release Capitolo o Saggio Go to
2014 Sterilization of three-dimensional tissue engineering scaffolds by supercritical carbon dioxide Proceedings Go to
2013 Novel proteases from marine organisms with potential interest in restoration procedure Proceedings Go to
2013 Radiation engineered polymer nanocarriers for a new generation of nanoparticles based tumor specific radiopharmaceuticals Proceedings Go to
2013 Heparin functionalized polyaspartamide/polyester scaffold for potential blood vessel regeneration Articolo in rivista Go to
2013 Structure and biological evaluation of amino-functionalized PVP nanogels for fast cellular internalization Articolo in rivista Go to
2013 Water-borne Polymeric Nanoparticles for Glutathione-Mediated Intracellular Delivery of Anticancer Drugs. Proceedings Go to
2013 Large-scale manufacturing of radiation sculptured therapeutic nanogels Contributo in atti di convegno pubblicato in volume Go to
2013 Poly-Left-Lactic Acid tubular scaffolds via Diffusion Induced Phase Separation (DIPS): control of morphology Articolo in rivista Go to
2013 PLLA-fibrin scaffolds for Vascular Tissue Engineering Proceedings Go to
2013 Dexamethasone Dipropionate Loaded Nanoparticles Of -Elastin-G-Plga For Potential Treatment Of Restenosis Articolo in rivista Go to
2013 Chemical hydrogels based on a hyaluronic acid-graft-α-elastin derivative as potential scaffolds for tissue engineering Articolo in rivista Go to
2013 Tissue engineered vascular grafts based on poly-lactic acid blends Altro Go to
2013 RUOLO DI ENZIMI PROTEOLITICI NELLA NEOANGIOGENESI TUMORALE. CROSS-TALK TRA CELLULE ENDOTELIALI, TUMORALI E MATRICE EXTRACELLULARE Altro Go to
2012 Titolo: Novel proteases from marine organisms with potential interest in restoration procedure Proceedings Go to
2012 Preparation and characterization of 3D PLA porous scaffolds Proceedings Go to
2012 BIO-PULITURA: PROTEASI DA ORGANISMI MARINI. Proceedings Go to
2012 Removal of old protein layers from surfaces of works of art by new enzymes Proceedings Go to
2012 Minimalism in Radiation Synthesis of Biomedical Functional Nanogels Articolo in rivista Go to
2012 3D polylactide-based scaffolds for studying human hepatocarcinoma processes in vitro Articolo in rivista Go to
2012 Radiation sculpured nanogels as platform for novel therapeutic systems Proceedings Go to
2012 Poly lactic acid based scaffolds as graft for small-diameter arterial replacement. Abstract in rivista Go to
2012 A Fibrillar Biodegradable Scaffold for Blood Vessels Tissue Engineering Capitolo o Saggio Go to
2012 Novel protese from marine organisms with potential interest in restoration procedures Proceedings Go to
2012 Polymeric Nanogels: Nanocarriers For Drug Delivery Application. Capitolo o Saggio Go to
2012 Use of Modified 3D Scaffolds to Improve Cell Adhesion and Drive Desired Cell Responses. Capitolo o Saggio Go to
2012 Poly lactic acid based scaffolds for vascular tissue engineering Articolo in rivista Go to
2012 Oligonucleotide-decorated carboxyl-modified PVP nanogels: a new platform for diagnosis and gene-therapy Proceedings Go to
2011 Polyactide Biodegradable Scaffolds for Tissue Engineering Applications: Phase Separation-Based Techniques Capitolo o Saggio Go to
2011 The effect of processing and molecular weight of poly(ethylenglycol) of polylactide-based scaffolds on viability and cell adhesion of SkHep1 cells Proceedings Go to
2011 Viabilità e adesione cellulare di cellule di epatocarcinoma umano su supporti 3D a base di poli(acido D,L lattico) Proceedings Go to
2011 The role of poly(ethylenglycol) molecular weight on viability and cell adhesion in polylactide based scaffolds Proceedings Go to
2011 Polylactide biodegradable scaffolds for tissue engineering applications phase separation-based techniques Capitolo o Saggio Go to
2011 Tissue Engineering Biopolymers Altro Go to
2011 Radiation engineered functionalized nanogels as platform for biomedical nanocarriers Proceedings Go to
2011 Nanocarriers to targeted terapy: a goal for biomedical applications. Altro Go to
2011 Poly(ethylenglycol) mimics adhesive capability of the ECM treatment on 3D polylactide-based scaffolds to study in vitro human hepatocarcinoma processes Proceedings Go to
2010 Muscle degeneration in neuramindase 1 deficient mice results from infiltration of the muscle fibers by expanded connective tissue Articolo in rivista Go to
2010 Pre-vascularized PLLA scaffolds: A new approcah to develop deep tissue regeneration Proceedings Go to
2010 C. HYSTOLITICUM RECOMBINANT COLLAGENASES AND METHOD FOR THE MANUFACTURE THEREOF Brevetto Go to
2010 A new method to value efficiency of enzyme blends for pancreas tissue digestion Articolo in rivista Go to
2010 SCAFFOLDS POLILATTIDICI PER APPLICAZIONI BIOMEDICHE Proceedings Go to
2010 A new method to value efficiency of enzyme blends for pancreatic tissue digestion. Articolo in rivista Go to
2010 A composite PLLA scaffold for regeneration of complex tissues. Proceedings Go to
2010 A COMPOSITE PLLA SCAFFOLD FOR REGENERATION OF COMPLEX TISSUES Articolo in rivista Go to
2009 PROCEDIMENTO DI PREPARAZIONE DI SCAFFOLD POLIMERICI PREANGIOGENIZZATI Brevetto Go to
2009 Macromolecular engineering of hydrogels: from macro to nano scalar materials for different levels of biointeraction Proceedings Go to
2009 EVALUATION OF STABILITY AND ENZYMATIC ACTIVITIES OF PROTEOLYTIC ENZYMES USED IN PANCREATIC ISLET TRANSPLANTATION Proceedings Go to
2009 ENGINEERED NANOGELS FOR BIOLOGICAL DRUGS TRANSPORT Proceedings Go to
2009 Bio-affinity of MC3T3-E1 osteoblastic cells with polymeric scaffold in Poly L-Lactid Acid (PLLA) for bone substitution. Proceedings Go to
2009 GENERATION OF PREVASCULARIZED PLLA BIODEGRADABLE SCAFFOLDS BY DIP DRAWING AND DIFFUSION INDUCED PHASE SEPARATION (DIPS). Proceedings Go to
2009 PLLA biodegradable scaffolds for Vascular Tissue Engineering (VTE) applications via dip drawing and Diffusion Induced Phase Separation (DIPS) Proceedings Go to
2009 A new method to valued efficiency of enzyme blend for pancreas tissue digestion. Proceedings Go to
2009 Could beta-catenin regulate the expression of proteolitic enzymes during angiogenesis? Proceedings Go to
2009 Identification of proteolytic enzymes from Eriphia verrucosa and Palinurus elephas capable to degrade gliadin Proceedings Go to
2009 Overespression of MT1-MMP modified the integrity of endothelial cell contact Proceedings Go to
2009 Comparative study on enzymatic activity and molecules stability of some commercial proteolytic enzymes used in pancreatic islet isolation. Proceedings Go to
2009 A new method to valued efficiency of enzyme blends for pancreas tissue digestion Proceedings Go to
2009 Procedimento di preparazione di scaffolds polimerici preangiogenizzati. Brevetto Go to
2009 COLLAGENASI RICOMBINANTI DI C. HISTOLYTICUM E METODO PER LA LORO PRODUZIONE. Brevetto Go to
2009 Patent number RM2009A000073: Procedimento di preparazione di scaffold polimerici preangiogenizzati Brevetto Go to
2009 Tailoring PLLA scaffolds for tissue engineering applications: Morphologies for 2D and 3D cell cultures Articolo in rivista Go to
2008 PLLA biodegradable scaffolds for angiogenesis via Diffusion Induced Phase Separation (DIPS) Abstract in rivista Go to
2008 Expression of proteolitic enzymes in induced angiogenesis Proceedings Go to
2008 Role of MT1-MMP in cell-cell contact formation of endothelial cells Proceedings Go to
2008 The use of Diffusion Induced Phase Separation (DIPS) technique for the preparation of biodegradable scaffolds for angiogenesis Proceedings Go to
2007 Matrix metalloproteases, serine proteases and their inhibitors in angiogenesis Capitolo o Saggio Go to
2007 Clustering and Proteolytic enzymes complexes formation in specialized plasma membra domains of endothelial cells. Role in angiogenesis. Proceedings Go to
2007 Proteolytic enzymes clustered in specialized plasma membrane domains generate permissive substrates for endothelial cell migration Proceedings Go to
2006 CLUSTERING OF TYPE-II TRANSMEMBRANE SERINE PROTEASES (TTSPS) AND MATRIX METALLOPROTEINASES (MMPS) IN THE CELL SURFACE AND SHED MEMBRANE VESICLES OF ACTIVE ENDOTHELIAL CELLS. Articolo in rivista Go to
2006 Vesicle mediated cell-cell and cell-matrix interactions Proceedings Go to
2006 Proteolytic enzymes expression during epithelial/mesenchymal transaction of endothelial cells Proceedings Go to
2006 Espressione ed associazione di enzimi proteolitici durante la transizione epitelio/mesenchima in cellule endoteliali. Proceedings Go to
2006 Differential expression of proteolytic enzymes during epithelial-mesenchymal transaction of endothelial cells. Proceedings Go to
2006 Activation of EDTA-resistant gelatinases in malignant human tumors Articolo in rivista Go to
2006 Type-II transmembrane prolyl dipeptidases and matrix metalloproteinases in membrane vesicles of active endothelial cells Articolo in rivista Go to
2006 Vesicles mediated cell-cell and cell-matrix interactions Proceedings Go to
2006 The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices Articolo in rivista Go to
2006 Comparative analyses of endothelial and tumoral cells cultured in 2D and 3D type-1 collagen fibril gels Proceedings Go to
2005 Proteolytic enzymes in membrane domains of endothelial cells cultured in type-I collagen 3D gels Proceedings Go to
2005 Clustering of type-II transmembrane serine proteases (TTSPs) and matrix metalloproteases (MMPs) in the cell surface and shed membrane vesicles of active endothelial cells Proceedings Go to
2004 CLUSTERING OF PROTEOLYTIC ENZYMES ON SPECIALIZED PLASMA MEMBRANE DOMAINS OF ENDOTHELIAL CELLS. ROLE IN ANGIOGENESIS Proceedings Go to
2004 Meccanismi non convenzionali di secrezione dell’FGF-2 Proceedings Go to
2003 Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells Articolo in rivista Go to
1997 Identification and characterization of a constitutive HSP75 in sea urchin embryos. Articolo in rivista Go to