| 2024 |
Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: synthesis, mechanistic insights and promising antitumor and safety profile |
Articolo in rivista |
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| 2024 |
Mechanisms of Sensitivity and Resistance to CDK4/CDK6 Inhibitors in Hormone Receptor-positive Breast Cancer Treatment |
Review essay (rassegna critica) |
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| 2024 |
Triazole derivatives inhibit the VOR complex-mediated nuclear transport of extracellular particles: Potential application in cancer and HIV-1 infection |
Articolo in rivista |
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| 2024 |
Exploring the therapeutic potential of focal adhesion kinase inhibition in overcoming chemoresistance in pancreatic ductal adenocarcinoma |
Review essay (rassegna critica) |
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| 2024 |
Exploring Splicing Modulation as an Innovative Approach to Combat Pancreatic Cancer: SF3B1 Emerges as a Prognostic Indicator and Therapeutic Target |
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| 2024 |
Novel [1,3,4]Thiadiazole[3,2-a]pyrimidin-5-ones as Promising Biofilm Dispersal Agents against Relevant Gram-Positive and Gram-Negative Pathogens |
Articolo in rivista |
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| 2023 |
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer |
Review essay (rassegna critica) |
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| 2023 |
Discovery of the 3-Amino-1,2,4-triazine-Based Library as Selective PDK1 Inhibitors with Therapeutic Potential in Highly Aggressive Pancreatic Ductal Adenocarcinoma |
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| 2023 |
1,2,4-Amino-triazine derivatives as pyruvate dehydrogenase kinase inhibitors: Synthesis and pharmacological evaluation |
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| 2023 |
Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy |
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| 2023 |
1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1 |
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| 2023 |
HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells |
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| 2023 |
Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma |
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| 2023 |
Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What is New? |
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| 2023 |
A Combination of Polymethoxyflavones from Citrus sinensis and Prenylflavonoids from Humulus lupulus Counteracts IL-1β-Induced Differentiated Caco-2 Cells Dysfunction via a Modulation of NF-κB/Nrf2 Activation |
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| 2023 |
Nortopsentins as Leads from Marine Organisms for Anticancer and Anti-Inflammatory Agent Development |
Review essay (rassegna critica) |
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| 2022 |
Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification |
Articolo in rivista |
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| 2022 |
Eight-Membered Rings With Two Heteroatoms 1,2 |
Capitolo o Saggio |
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| 2022 |
Eight-Membered Rings With Two Heteroatoms 1,3 |
Capitolo o Saggio |
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| 2022 |
Eight-Membered Rings With Two Heteroatoms 1,5 |
Capitolo o Saggio |
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| 2022 |
Biofilm Formation as Valuable Target to Fight against Severe Chronic Infections |
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| 2022 |
Synthesis and cytotoxic activity of 3-[2-(1H-Indol-3-yl)-1,3-thiazol-4-yl]-1Hpyrrolo[3,2-c]pyridine hydrobromides, analogues of the marine alkaloid nortopsentin |
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| 2022 |
A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells |
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| 2022 |
Synthesis and Antioxidative Properties of 1,2,3,4-Tetrahydropyridine Derivatives with Different Substituents in 4-Position |
Articolo in rivista |
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| 2022 |
Eight-membered heterocycles with two heteroatoms in a 1,3-relationship of interest in medicinal chemistry |
Capitolo o Saggio |
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| 2021 |
Novel strategies in the war against antibiotic resistance |
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| 2021 |
Analysis of the metabolic switch induced by the spirulina peptide SP6 in high fat diet ApoE-/-mice model: A direct infusion FT-ICR-MS based approach |
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| 2021 |
Hop-derived fraction rich in beta acids and prenylflavonoids regulates the inflammatory response in dendritic cells differently from quercetin: unveiling metabolic changes by mass spectrometry-based metabolomics |
Articolo in rivista |
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| 2021 |
SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance |
Articolo in rivista |
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| 2021 |
Eight-membered heterocycles with two heteroatoms in a 1,2-relationship of interest in medicinal chemistry |
Capitolo o Saggio |
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| 2021 |
Cyclin dependent kinase-1 (Cdk-1) inhibition as a novel therapeutic strategy against pancreatic ductal adenocarcinoma (pdac) |
Review essay (rassegna critica) |
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| 2021 |
A bug in the resistance to EGFR inhibitors: is there a role for Mycoplasma and cytidine deaminase in reducing the activity of osimertinib in lung cancer patients? |
Lettera |
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| 2021 |
CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin |
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| 2021 |
GSK3β as a novel promising target to overcome chemoresistance in pancreatic cancer |
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| 2021 |
Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy |
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| 2021 |
1,2,4-Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase |
Articolo in rivista |
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| 2021 |
Dynamic-shared pharmacophore approach as tool to design new allosteric PRC2 inhibitors, targeting EED binding pocket |
Articolo in rivista |
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| 2021 |
1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A |
Articolo in rivista |
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| 2021 |
Therapeutic strategies to counteract antibiotic resistance in MRSA biofilm-associated infections |
Review essay (rassegna critica) |
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| 2021 |
Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation |
Articolo in rivista |
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| 2020 |
New Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives Inhibit FAK Phosphorylation and Potentiate the Antiproliferative Effects of Gemcitabine Through Modulation of the Human Equilibrative Nucleoside Transporter-1 in Peritoneal Mesothelioma |
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| 2020 |
Inhibitors of antibiotic resistance mechanisms: clinical applications and future perspectives |
Articolo in rivista |
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| 2020 |
Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance |
Articolo in rivista |
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| 2020 |
3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1HIndole derivatives as new anticancer agents in the treatment of pancreatic ductal adenocarcinoma |
Articolo in rivista |
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| 2020 |
Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry |
Capitolo o Saggio |
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| 2020 |
Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells |
Articolo in rivista |
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| 2020 |
Open Sesame? : Biomarker Status of the Human Equilibrative Nucleoside Transporter-1 and Molecular Mechanisms Influencing its Expression and Activity
in the Uptake and Cytotoxicity of Gemcitabine in Pancreatic Cancer |
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| 2019 |
Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives against Pancreatic Cancer Cells* |
Articolo in rivista |
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| 2019 |
Synthesis of novel 1,2,4-oxadiazole topsentin analogs with antitumor activity |
Contributo in atti di convegno pubblicato in volume |
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| 2019 |
Biological evaluation of new 1,2,4-oxadiazole topsentin analogs as anticancer agents |
Abstract in atti di convegno pubblicato in volume |
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| 2018 |
Resistance to epidermal growth factor receptor inhibition in non-small cell lung cancer |
Articolo in rivista |
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