The inhibitory effect of D-glucosamine on thymidine kinase in chick embryo retinas and HeLa cells
- Authors: TESORIERE, G; TESORIERE, L; VENTO, R; GIULIANO, M; CANTORO, G
- Publication year: 1984
- Type: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/65956
Abstract
D-Glucosamine markedly inhibits thymidine incorporation into the TCA-insoluble fraction and thymidine kinase activity in HeLa cells. Both the inhibitory effects are also observed in isolated retinas of chick embryos. In this case the inhibitory effects are age-dependent and the magnitude of the responses decreases with embryonic development. In addition the time of exposure to D-glucosamine which is necessary to reveal the inhibitory effect on thymidine kinase increases with the age of the embryos.