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Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

  • Autori: Domarco O.; Lotsch D.; Schreiber J.; Dinhof C.; Van Schoonhoven S.; Garcia M.D.; Peinador C.; Keppler B.K.; Berger W.; Terenzi A.
  • Anno di pubblicazione: 2017
  • Tipologia: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/392738

Abstract

Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.