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SERGIO SIRAGUSA

A Difficult Case of Ventriculitis in a 40-Year-Old Woman with Acute Myeloid Leukemia

  • Authors: Rubino, Raffaella; Trizzino, Marcello; Pipitò, Luca; Sucato, Giuseppe; Santoro, Marco; Maugeri, Rosario; Iacopino, Domenico Gerardo; Giammanco, Giovanni Maurizio; Siragusa, Sergio; Cascio, Antonio
  • Publication year: 2024
  • Type: Articolo in rivista
  • Key words: central nervous system infection; meropenem/vaborbactam; multidrug resistance; ventriculitis
  • OA Link: http://hdl.handle.net/10447/639899

Abstract

Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge. A case of ventriculitis and bacteremia caused by carbapenem-resistant, KPC-producing Klebsiella pneumoniae and vancomycin-resistant Enterococcus faecium in a young woman with acute leukemia who was successfully treated with meropenem/vaborbactam (MVB), rifampicin, and linezolid is described in this paper. This case report emphasizes the importance of a multidisciplinary strategy, including infectious focus control, for the treatment of device-associated central nervous system (CNS) infections from multidrug-resistant bacteria. Considering the novel resistance patterns, more research on drug penetration into the central nervous system, as well as on the necessity of association therapies, is needed.