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SERGIO SIRAGUSA

Tailoring haemophilia A prophylaxis with BAY 81-8973: A case series

  • Authors: Santoro, Rita Carlotta; Giuffrida, Gaetano; Daniele, Filomena; Gagliano, Fabio; Mansueto, Maria Francesca; Calafiore, Valeria; Siragusa, Sergio; Napolitano, Mariasanta
  • Publication year: 2020
  • Type: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/430607

Abstract

BAY 81-8973 is an unmodified, full-length third generation recombinant factor VIII (rFVIII) which offers a more favorable pharmacokinetic (PK) profile, compared to its predecessor sucrose-formulated rFVIII (rFVIII-FS). We here report on a retrospective case series of nine patients affected by hemophilia A (HA), with variable disease severity, bleeding phenotype and comorbidities, to underline our clinical practice on prophylaxis with a recently introduced standard hall-life recombinant Factor VIII. The current case series highlights how the current clinical management of hemophilia is able to personalize treatment in several specific conditions like concomitant illnesses with thrombotic risk and allergic reactions.