Clinical Utility of Midregional Proadrenomedullin in Patients with COVID-19
- Authors: Lo Sasso, Bruna; Gambino, Caterina Maria; Scichilone, Nicola; Giglio, Rosaria Vincenza; Bivona, Giulia; Scazzone, Concetta; Muratore, Roberto; Milano, Salvatore; Barbagallo, Mario; Agnello, Luisa; Ciaccio, Marcello
- Publication year: 2021
- Type: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/517229
Abstract
Objective: The aim of the study was to assess the role of midregional proadrenomedullin (MR-proADM) in patients with COVID-19. Methods: We included 110 patients hospitalized for COVID-19. Biochemical biomarkers, including MR-proADM, were measured at admission. The association of plasma MR-proADM levels with COVID-19 severity, defined as a requirement for mechanical ventilation or in-hospital mortality, was evaluated. Results: Patients showed increased levels of MR-proADM. In addition, MR-proADM was higher in patients who died during hospitalization than in patients who survived (median, 2.59 nmol/L; interquartile range, 2.3-2.95 vs median, 0.82 nmol/L; interquartile range, 0.57-1.03; P <.0001). Receiver operating characteristic curve analysis showed good accuracy of MR-proADM for predicting mortality. A MR-proADM value of 1.73 nmol/L was established as the best cutoff value, with 90% sensitivity and 95% specificity (P <.0001). Conclusion: We found that MR-proADM could represent a prognostic biomarker of COVID-19.