A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population
- Autori: Liguori, M.; Sawcer, S.; Setakis, E.; Compston, A.; Giordano, M.; D'Alfonso, S.; Mellai, M.; Malferrari, G.; Trojano, M.; Livrea, P.; De Robertis, F.; Massacesi, L.; Repice, A.; Ballerini, C.; Biagioli, T.; Bomprezzi, R.; Cannoni, S.; Ristori, G.; Salvetti, M.; Grimaldi, L.; Biunno, I.; Comi, G.; Leone, M.; Ferro, I.; Naldi, P.; Milanese, C.; Gellera, C.; Loredana, L.; Savettieri, G.; Salemi, G.; Aridon, P.; Caputo, D.; Guerini, F.; Ferrante, P.; Momigliano-Richiardi, P.
- Anno di pubblicazione: 2003
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: DNA pools; Microsatellites; Multiple sclerosis; Whole genome linkage disequilibrium; Immunology; Neurology (clinical); Immunology and Allergy; Neurology
- OA Link: http://hdl.handle.net/10447/207738
Abstract
We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case-control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association. © 2003 Elsevier B.V. All rights reserved.