Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles
- Authors: Tinnirello, Vincenza; Rabienezhad Ganji, Nima; De Marcos Lousa, Carine; Alessandro, Riccardo; Raimondo, Stefania
- Publication year: 2023
- Type: Review essay (rassegna critica)
- OA Link: http://hdl.handle.net/10447/585791
Abstract
: The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model for the design of innovative delivery systems. In this review, a summary of the prerequisites for mammalian extracellular vesicles to serve as delivery vehicles will be given. After that, we will concentrate on providing a thorough overview of the studies investigating the interactions of plant-derived nanoparticles with mammalian systems as well as the loading strategies for encapsulating therapeutic molecules. Finally, the existing challenges in establishing PDNPs as reliable biological delivery systems will be emphasized.