Cisplatin derivative loaded in mesoporous MCM-41: preparation and characterization

Abstract

The aim of this study is to design and investigate a new material constituted by mesoporous silica MCM-41 and a new cisplatin derivative, cis-PtCl2(DMSO)HL]•2DMSO, where HL = 7-amino-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid, having biological activity.[1] The high surface area and the tunable pore size of MCM-41 allow it for loading vast amounts of bioactive molecules, including biocides and drugs. Mesoporous silica MCM-41 was prepared in alkaline environment from tetraethoxysilane as Si source and cetyltrimethylammonium bromide (CTAB) as template. [2] Amino groups have been successfully grafted onto the pore surface with 3-aminopropyl triethoxysilane (APTES) in order to create favorable surface-drug interactions. The encapsulation of the drug was performed adding the MCM-41-NH2 in a PtCl2(DMSO)HL]•2DMSO chloroform solution. The characterization of materials was performed by X-ray diffraction, N2 adsorption and solid state NMR (29Si and 13C). Results showed that the amino groups serve as effective ligands for the linking of Pt atoms to the mesoporous. The controlled release of the PtCl2(DMSO)HL]•2DMSO in water was investigated.