Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO
- Authors: Adamo D.; Calabria E.; Canfora F.; Coppola N.; Leuci S.; Mignogna M.; Muzio L.L.; Spirito F.; Giuliani M.; Azzi L.; Dani M.; Colella G.; Colella C.; Montebugnoli L.; Gissi D.B.; Gabriele M.; Nisi M.; Sardella A.; Lodi G.; Varoni E.M.; Giudice A.; Antonelli A.; Gambino A.; Antonucci G.; Vescovi P.; Meleti M.; Majorana A.; Bardellini E.; Campisi G.; Panzarella V.; Spadari F.; Garagiola U.; Pentenero M.; Sutera S.; Biasotto M.; Ottaviani G.; Gobbo M.; Nardini L.G.; Romeo U.; Tenore G.; Serpico R.; Lucchese A.; Lajolo C.; Gioco G.; Aria M.; D'Aniello L.; Mignogna M.D.
- Publication year: 2023
- Type: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/625573
Abstract
ObjectivesOral lichen planus with exclusive keratotic reticular, papular, and/or plaque-like lesions (K-OLP) is a clinical pattern of OLP that may be associated with a complex symptomatology and psychological alteration. The aim of the study was to evaluate the prevalence of anxiety (A) and depression (D) in patients with K-OLP, analyzing the potential predictors which can affect mental health status.MethodsThree hundred K-OLP patients versus 300 healthy controls (HC) were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), and Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A) were administered.ResultsThe K-OLP patients showed statistically higher scores in the NRS, T-PRI, HAM-D, and HAM-A compared with the HC (p-value < 0.001*). A and D were found in 158 (52.7%) and 148 (49.3%) K-OLP patients. Strong linear correlations were identified between HAM-A, HAM-D, NRS, T-PRI, and employment status and between HAM-D, HAM-A, NRS, T-PRI, employment status, and female gender. Multivariate logistic regression revealed that HAM-D and HAM-A showed the greatest increase in the R2 value for A and D in the K-OLP patients, respectively (DR2 = 55.5% p-value < 0.001**; DR2 = 56.5% p-value < 0.001**).ConclusionsThe prevalence of A and D is higher in the K-OLP patients compared with the HC, also found in K-OLP subjects without pain, suggesting that the processing of pain may be in a certain way independent of the processing of mood.