Natural Inhibitors of P-glycoprotein in AcuteMyeloid Leukemia
- Autori: Manuela Labbozzetta; Paola Poma; Monica Notarbartolo
- Anno di pubblicazione: 2023
- Tipologia: Review essay (rassegna critica)
- OA Link: http://hdl.handle.net/10447/590696
Abstract
Acute myeloid leukemia (AML) remains an insidious neoplasm due to the percentage of patients who develop resistance to both classic chemotherapy and emerging drugs. Multidrug resistance (MDR) is a complex process determined by multiple mechanisms, and it is often caused by the overexpression of efflux pumps, the most important of which is P-glycoprotein (P-gp). This minireview aims to examine the advantages of using natural substances as P-gp inhibitors, focusing on four molecules: phytol, curcumin, lupeol, and heptacosane, and their mechanism of action in AML.