Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease
- Autori: Rosso C.; Caviglia G.P.; Birolo G.; Armandi A.; Pennisi G.; Pelusi S.; Younes R.; Liguori A.; Perez-Diaz-del-Campo N.; Nicolosi A.; Govaere O.; Castelnuovo G.; Olivero A.; Abate M.L.; Ribaldone D.G.; Fariselli P.; Valenti L.; Miele L.; Petta S.; Romero-Gomez M.; Anstee Q.M.; Bugianesi E.
- Anno di pubblicazione: 2023
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/619560
Abstract
Background and aims: Nonalcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism rs738409 C>G in the PNPLA3 gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analyzed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim to identify individuals in whom genetics may have a stronger impact on disease progression. Methods: We retrospectively analyzed 756 consecutive, prospectively enrolled biopsy-proven NAFLD subjects from Italy, United Kingdom, and Spain who were followed for a median of 84 months (interquartile range, 65-109 months). We stratified the study cohort according to sex, body mass index (BMI)