Dimethyl 2,2′‐[carbonylbis(Azanediyl)](2s,2′s)‐bis[3‐(4‐hydroxyphenyl)propanoate]
- Authors: Mancuso, Raffaella*; Gioia, Katia F.; Palumbo Piccionello, Antonio; Della Ca’, Nicola; Carfagna, Carla; Gabriele, Bartolo
- Publication year: 2018
- Type: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/351038
Abstract
The thus‐far unknown ureic derivative dimethyl 2,2′‐[carbonylbis(azanediyl)](2S,2′S)‐ bis[3‐(4‐hydroxyphenyl)propanoate] has been efficiently synthesized by enantiospecific oxidative carbonylation of readily available L‐tyrosine methyl ester, using a very simple catalytic system (PdI2 in conjunction with KI) under relatively mild conditions (100 °C for 5 h in DME as the solvent and under 20 atm of a 4:1 mixture CO‐air).