Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives
- Autori: Palumbo Piccionello, A; Musumeci, R; Cocuzza, C; Fortuna, CG; Guarcello, A; Pierro, P; Pace, A
- Anno di pubblicazione: 2012
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: Oxazolidinone 1,2,4-Oxadiazole Linezolid Antimicrobial activity Fluorinated heterocycles
- OA Link: http://hdl.handle.net/10447/63144
Abstract
In the present study the synthesis of new Linezolid-like molecules has been achieved by substitution of the oxazolidinone central heterocyclic moiety with a 1,2,4-oxadiazole ring. Two series of 1,2,4-oxadiazoles, bearing different side-chains and containing a varying number of fluorine atoms, were synthesized and preliminarily tested for biological activity against some Gram-positive and Gramnegative bacteria using Linezolid and Ceftriaxone as reference drugs.