rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease
- Authors: KOCH G; BRUSA L; CALTAGIRONE C; PEPPE A; OLIVERI M; STANZIONE P; CENTONZE D
- Publication year: 2005
- Type: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/31629
Abstract
The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.