Phenotypic APC resistance as a marker of hypercoagulability in primitive cerebral lymphoma
- Autori: De Lucia, Domenico; De Francesco, Francesco; Marotta, Rosa; Maisto, Giovanna; Meo, Daniela; Sessa, Marcella; Misso, Margherita; Galante, Maria; Russo, Teresa; Pignalosa, Orlando; Napolitano, Mariasanta; Papa, Maria Luisa; Niglio, Alferio; Di Micco, Pierpaolo
- Anno di pubblicazione: 2005
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: Blood Coagulation; Brain Neoplasms; Case-Control Studies; Factor V; Humans; Ischemic Attack, Transient; Lymphoma, Non-Hodgkin; Mutation; Peptide Fragments; Phenotype; Plasminogen Activator Inhibitor 1; Prothrombin; Stroke; Activated Protein C Resistance; Biomarkers
- OA Link: http://hdl.handle.net/10447/350536
Abstract
Thrombosis is the most frequent complication and the second cause of death in patients with malignant disease. Primary central nervous system non-Hodgkin's lymphoma represents a rare pathology. Resistance to APC is usually linked to a factor V (FV) gene mutation changing an Arg 506 to a Gln in the APC cleavage site.