Multicenter validation of the magnetic resonance T2* technique for segmental and global quantification of myocardial iron.
- Authors: Ramazzotti, A; Pepe, A; Positano, V; Rossi, GG; De Marchi, D; Brizi, MG; Luciani, A; Midiri, M; Sallustio, G; Valeri, G; Caruso, V; Centra, M; Cianciulli, P; De Sanctis, V; Maggio, A; Lombardi, M
- Publication year: 2009
- Type: Articolo in rivista (Articolo in rivista)
- Key words: myocardial iron; T2* technique;
- OA Link: http://hdl.handle.net/10447/46908
Abstract
PURPOSE: To assess the transferability of the magnetic resonance imaging (MRI) multislice multiecho T2(*) technique for global and segmental measurement of iron overload in thalassemia patients. MATERIALS AND METHODS: Multiecho T2(*) sequences were installed on six MRI scanners. Five healthy subjects (n = 30) were scanned at each site; five thalassemia major (TM) patients were scanned at the reference site and were rescanned locally (n = 25) within 1 month. T2(*) images were analyzed using previously validated software. RESULTS: T2(*) values of healthy subjects showed intersite homogeneity. On TM patients, for global heart T2(*) values the correlation coefficient was 0.97, coefficients of variation (CoV(s)) ranged from 0.04-0.12, and intraclass coefficients (ICC(s)) ranged from 0.94-0.99. The mean CoV and ICC for segmental T2(*) distribution were 0.198 and 88, respectively. CONCLUSION: The multislice multiecho T2(*) technique is transferable among scanners with good reproducibility. (c) 2009 Wiley-Liss, Inc.