Clay-biosurfactant materials as functional drug delivery systems: Slowing down effect in the in vitro release of cinnamic acid

Abstract

The main objectives of the present paper were the preparation and characterization of new surfactant-modified clays and the evaluation of their potential applicability as drug delivery systems for the oral administration of the cinnamic acid (CA) drug. The organoclays (OC) were prepared by loading different amounts of the biocompatible nonionic polyoxyethylene sorbitan monolaurate surfactant (Tween20) onto K10 montmorillonite (Mt) clay and characterized through the construction of the adsorption isotherms by means of the spectrophotometric method. The performance of the prepared material was verified by gathering the adsorption isotherms of the cinnamic acid onto the Mt/Tween20 organoclay and by monitoring the release profiles in both simulated gastric (SGF) and intestinal fluids (SIF). The quantitative analysis of the adsorption isotherms revealed that the uptake of the aromatic component onto both the blank and Tween20-loaded Mt was governed by positive cooperative processes and that the presence of the bio-surfactant enhanced the loading efficiency of the clay. By relating the raw montmorillonite uptake capability with that of the OC it was assessed that the presence of the bio-surfactant enhanced about 2 times the loading efficiency of the clay. From the XRD characterization of the obtained complexes, the successful intercalation of the drug into the prepared organoclay was demonstrated. Very useful information was obtained by the in vitro release studies, which showed that the release of the drug from both the clay and organoclay was prolonged in comparison with the pharmacokinetics of the free drug. Besides, the intercalation of the surfactant into the nano-carrier ensured the complete release of the CA after oral drug administration and the kinetics of the release process was strongly dependent on the type of drug formulation used, which means that the CA release can be modulated by properly functionalizing the clay surface.