Ruolo delle heat shock proteins nella patogenesi della miastenia gravis

Abstract

Myasthenia Gravis (MG) is an autoimmune disorder of the neuromuscolar junction mediated by specific antibodies to the nicotinic acetylcholine receptors. Several clinical and experimental studies have confirmed that the HSPs are involved in the process of regulation of some autoimmune disorders such as arthritis, diabetes, atherosclerosis and multiple sclerosis. The involvement of HSPs within different autoimmune disorders allows to hypothesize their presence in the pathogenesis of the MG, i.e. as suggested by the existence of a cross-reactivity among the antigenic epitopes of Hsp60 and AChR. Moreover, since a cross-reactivity between human and bacterial epitopes of Hsp60 has also been described, we would like to stress the role played by chronic and/or persistent infections, such as those from Chlamydia Trachomatis. © Capsula Eburnea, 2010.