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ANTONELLA MARIA MAGGIO

Furostanol saponins and ecdysones with cytotoxic activity from Helleborus bocconei ssp. intermedius

  • Authors: Rosselli, S; Maggio, AM; Bruno, M; Spadaro, V; Formisano, C; Irace, C; Maffettone, C; Mascolo, N
  • Publication year: 2009
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: H. bocconei subsp. intermedius; Ranunculaceae; furostanol saponins; C6 glioma cells; cytotoxic activity
  • OA Link: http://hdl.handle.net/10447/38425

Abstract

Two furostanol saponins helleboroside A (1) and helleboroside B (2) were isolated from the methanol extract of Helleborus bocconei Ten. subsp. intermedius (Guss.) Greuter and Burdet, along with the furospirostanol saponin 4 and two ecdysones: ecdysterone (5) and polypodyne B (6). Compound 2 was enzymatically hydrolysed to give product 3. The biological activity of all compounds was tested against rat C6 glioma cells showing a significant cytotoxicity for compounds 3, 4 and 6. Copyright © 2009 John Wiley & Sons, Ltd.