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ANTONELLA MARIA MAGGIO

Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa (Desf.) DC (Apiaceae)

  • Authors: ROSSELLI S; MAGGIO A; BELLONE G; FORMISANO C; BASILE A; CICALA C; ALFIERI A; MASCOLO N; BRUNO M
  • Publication year: 2007
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/25909

Abstract

The phytochemical investigation of the acetone and methanol extracts of the flowers of Magydaris tomentosa (Desf.) DC afforded six known coumarins as well as (+)-meranzin hydrate (7), not previously reported as a natural product. The antibacterial activity of umbelliprenin (1), osthol (2), imperatorin (3), citropten (4) and (+)-meranzin hydrate (7) was tested against Gram-positive and Gram-negative bacteria. All coumarins (1-7) isolated in this study inhibited growth of all bacterial strains tested (MIC between 16 and 256 μg/mL), the most active being imperatorin (3) (MICs between 32 and 128 μg/mL) and citropten (4) (MICs between 16 and 256 μg/mL). The anticoagulant activity of compounds 1-4 and 7 was also evaluated.