Aromatase inhibitors in male infertility. Letrozole - place in therapy

Abstract

There is no reliable treatment for men with idiopathic infertility, but the relationship between severe sperm production and the ratio of estrogen to testosterone levels has been shown. Aromatase is an enzyme that plays an important role in converting testosterone to estradiol and androstenedione to estrogen. And Aromatase inhibitors can increase testosterone and androgen production without increasing the amount of estrogen in circulation. One of the highlights of this book is an exploration of Letrozole, a medication originally developed for treating breast cancer, but now showing promising results as an innovative treatment for male infertility. We explored Letrozole’s mode of action and the clinical data that supports its administration, giving readers a thorough grasp of how it can revolutionize the field of treating male infertility. This book aims to apprise the readers about the various aspects of male infertility, approach to management of the condition and role of Letrozole in male infertility treatment, as well as clinical evidence-based discussions on the results of trials and research from across the globe. Our intent is to provide a solid foundation of knowledge that would help healthcare workers rely on, when dealing with cases of male infertility while still presenting the limitations.