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ANTONIO SIMONE LAGANÀ

D-chiro-inositol in clinical practice: A perspective from The Experts Group on Inositol in Basic and Clinical Research (EGOI)

  • Authors: Dinicola, Simona; Unfer, Vittorio; Soulage, Christophe O; Yap-Garcia, Maria Isidora Margarita; Bevilacqua, Arturo; Benvenga, Salvatore; Barbaro, Daniele; Wdowiak, Artur; Nordio, Maurizio; Dewailly, Didier; Appetecchia, Marialuisa; Aragona, Cesare; Espinola, Maria Salomè Bezerra; Bizzarri, Mariano; Cavalli, Pietro; Colao, Annamaria; D'Anna, Rosario; Vazquez-Levin, Mónica Hebe; Hernàndez Marin, Imelda; Kamenov, Zdravko; Laganà, Antonio Simone; Monastra, Giovanni; Montanino Oliva, Mario; Cenk Özay, Ali; Pintaudi, Basilio; Porcaro, Giuseppina; Pustotina, Olga; Pkhaladze, Lali; Prapas, Nikos; Roseff, Scott; Salehpour, Saghar; Stringaro, Annarita; Tugushev, Marat; Unfer, Virginia; Vucenik, Ivana; Facchinetti, Fabio
  • Publication year: 2024
  • Type: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/627733

Abstract

Background: D-chiro-inositol is a natural molecule that, in association with its well-studied isomer myo-inositol, may play a role in treating various metabolic and gynecological disorders. Objectives: This perspective seeks to explore the mechanisms and functions of D-chiro-inositol, laying the foundations to discuss its use in clinical practice, across dysmetabolism, obesity, and hormonal dysregulation. Methods: A narrative review of all the relevant papers known to the authors was conducted. Outcome: D-chiro-inositol acts through a variety of mechanisms, acting as an insulin sensitizer, inhibiting the transcription of aromatase, in addition to modulating white adipose tissue/brown adipose tissue trans differentiation. These different modes of action have potential applications in a variety of therapeutic fields including: PCOS, dysmetabolism, obesity, hypoestrogenic/hyperandrogenic disorders, and bone health. Conclusions: D-chiro-inositol mode of action has been studied in detail in recent years, resulting in a clear differentiation between D-chiro-inositol and its isomer myo-inositol. The insulin sensitizing activities of D-chiro-inositol are well understood; however, its potential applications in other fields, in particular obesity and hyperestrogenic/hypoandrogenic disorders in men and women, represent promising avenues of research that require further clinical study.