Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma
- Autori: Giannitrapani, L.; Cervello, M.; Soresi, M.; Notarbartolo, M.; La Rosa, M.; Virruso, L.; D'Alessandro, N.; Montalto, G.
- Anno di pubblicazione: 2002
- Tipologia: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/198026
Abstract
Interleukin-6 plays a central role in regulating the immune system, hematopoiesis, and acute phase reaction. It interacts with a receptor complex consisting of a specific ligand-binding protein (IL-6R, gp80) and a signal transduction protein (gp130). In this report, serum levels of IL-6 and a soluble form of the interleukin-6 receptor (sIL-6R) were evaluated in patients with hepatocellular carcinoma. The correlation between IL-6 and sIL-6R values, the stage of hepatocellular carcinoma, and main liver function tests was also studied.