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GIUSEPPE MIRKO NAZARENO GALLO

PCL/PEG based membranes for bacterial cells immobilization stimulate actinorhodin antibiotic production in S. coelicolor

  • Authors: Sutera, A.; Fontana, R.; Lopresti, F.; Botta, L.; Puglia, A.; Scaffaro, R.; Gallo, G.
  • Publication year: 2015
  • Type: Abstract in atti di convegno pubblicato in volume
  • Key words: Cell-immobilization; actinorhodin and biomass production; PCL/PEG membranes.
  • OA Link: http://hdl.handle.net/10447/254836

Abstract

The actinomycetes, Gram-positive filamentous bacteria, are the most prolific source of natural antibiotics. At industrial level, antibiotics from actinomycetes are usually produced at low levels by mean of fermentative processes in submerged cultivations, where one of the major factors negatively affecting bioproductivity is the phenomenon of a pellet-shaped biomass growth. The strategies based on cell-immobilization, which were already proven improving bacterial bioprocess productivity, could stimulate antibiotic production in actinomycetes.