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GIROLAMO GERACI

Persistence of Nonceliac Wheat Sensitivity, Based on Long-term Follow-up

  • Authors: Carroccio, A.; D'Alcamo, A.; Iacono, G.; Soresi, M.; Iacobucci, R.; Arini, A.; Geraci, G.; Fayer, F.; Cavataio, F.; La Blasca, F.; Florena, A.; Mansueto, P.
  • Publication year: 2017
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/240552

Abstract

We investigated how many patients with a diagnosis of nonceliac wheat sensitivity (NCWS) still experienced wheat sensitivity after a median follow-up time of 99 months. We collected data from 200 participants from a previous study of NCWS, performed between July and December 2016 in Italy; 148 of these individuals were still on a strict wheat- free diet. In total, 175 patients (88%) improved (had fewer symptoms) after a diagnosis of NCWS; 145 of 148 patients who adhered strictly to a gluten-free diet (98%) had reduced symptoms, compared with 30 of 52 patients who did not adhere to a gluten-free diet (58%) (P < .0001). Of the 22 patients who repeated the double-blind, placebo- controlled challenge, 20 reacted to wheat. We conclude that NCWS is a persistent condition. Clinicaltrials.gov registration number: NCT02823522.