In vitro and in vivo anticryptococcal activities of a new pyrazolo-isothiazole derivative
- Autori: Barchiesi, Francesco*; Milici, Maria E.; Arzeni, Daniela; Schimizzi, Anna M.; Pizzo, Giuseppe; Giammanco, Giovanni; Giannini, Daniele; Manfrini, Maurizio; Scalise, Giorgio; Vicentini, Chiara B.
- Anno di pubblicazione: 2003
- Tipologia: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/344199
Abstract
We investigated the activity of a pyrazolo-isothiazole derivative (G8) against Cryptococcus neoformans. A first screening test showed that G8 at 10 mg/L inhibited the growth of 14 of 15 clinical isolates tested. Killing experiments showed that fungicidal activity was achieved after 8 h of treatment with G8 at concentrations ≥10 mg/L. In a murine model of systemic cryptococcosis, G8 was effective at prolonging survival compared with the controls. Our data indicate that this new derivative has a potential therapeutic role in infections caused by C. neoformans.