Protective mechanical ventilation during general anesthesia for open abdominal surgery improves postoperative pulmonary function
- Authors: Severgnini, P.; Selmo, G.; Lanza, C.; Chiesa, A.; Frigerio, A.; Bacuzzi, A.; Dionigi, G.; Novario, R.; Gregoretti, C.; De Abreu, M.; Schultz, M.; Jaber, S.; Futier, E.; Chiaranda, M.; Pelosi, P.
- Publication year: 2013
- Type: Articolo in rivista (Articolo in rivista)
- Key words: Abdomen; Aged; Anesthesia, General; Female; Follow-Up Studies; Humans; Intraoperative Care; Lung Diseases; Male; Positive-Pressure Respiration; Postoperative Complications; Postoperative Period; Prospective Studies; Respiration, Artificial; Respiratory Function Tests; Tidal Volume; Treatment Outcome; Anesthesiology and Pain Medicine
- OA Link: http://hdl.handle.net/10447/157072
Abstract
BACKGROUND:: The impact of intraoperative ventilation on postoperative pulmonary complications is not defined. The authors aimed at determining the effectiveness of protective mechanical ventilation during open abdominal surgery on a modified Clinical Pulmonary Infection Score as primary outcome and postoperative pulmonary function. METHODS:: Prospective randomized, open-label, clinical trial performed in 56 patients scheduled to undergo elective open abdominal surgery lasting more than 2 h. Patients were assigned by envelopes to mechanical ventilation with tidal volume of 9 ml/kg ideal body weight and zero-positive end-expiratory pressure (standard ventilation strategy) or tidal volumes of 7 ml/kg ideal body weight, 10 cm H2O positive end-expiratory pressure, and recruitment maneuvers (protective ventilation strategy). Modified Clinical Pulmonary Infection Score, gas exchange, and pulmonary functional tests were measured preoperatively, as well as at days 1, 3, and 5 after surgery. RESULTS:: Patients ventilated protectively showed better pulmonary functional tests up to day 5, fewer alterations on chest x-ray up to day 3 and higher arterial oxygenation in air at days 1, 3, and 5 (mmHg; mean ± SD): 77.1 ± 13.0 versus 64.9 ± 11.3 (P = 0.0006), 80.5 ± 10.1 versus 69.7 ± 9.3 (P = 0.0002), and 82.1 ± 10.7 versus 78.5 ± 21.7 (P = 0.44) respectively. The modified Clinical Pulmonary Infection Score was lower in the protective ventilation strategy at days 1 and 3. The percentage of patients in hospital at day 28 after surgery was not different between groups (7 vs. 15% respectively, P = 0.42). CONCLUSION:: A protective ventilation strategy during abdominal surgery lasting more than 2 h improved respiratory function and reduced the modified Clinical Pulmonary Infection Score without affecting length of hospital stay. Copyright © 2013, the American Society of Anesthesiologists, Inc. Lippincott Williams & Wilkins.