The importance of the interactions between KIRs and HLA ligands in the development of human autoimmune and viral diseases

Abstract

Killer immunoglobulin-like receptors (KIRs) regulate the activation of natural killer cells through their interaction with human leucocyte antigens (HLA). KIR and HLA loci are highly polymorphic, and certain KIR/HLA combinations have been found to protect against viral infections or to predispose to autoimmune disorders. In particular, some activating KIR profiles may be detrimental in autoimmune pathogenesis, and specific KIR genes may be particularly aggressive in the clearance of different microorganisms, protecting individuals in the control of a given pathogen. Here we reviewed a growing body of evidence purporting the influence of KIR polymorphism and KIR-HLA interaction in the development of the main human autoimmune and viral diseases.