SYNTHESIS AND CHARACTERIZATION OF POSITIVELY CHARGED FUNCTIONALIZED HALLOYSITE/CURCUMIN SYSTEMS AND EVALUATION OF THEIR ANTICANCER ACTIVITY

Abstract

Phenolic compound originated from one of the main class of secondary metabolites, as curcumin and its derivatives have been studied and their biological and pharmacological activities have been evaluated, too [1,2]. Unfortunately, curcumin exhibits poor bioavailability after oral or topic administration [3]. Therefore a carefully designed carrier could significantly facilitate curcumin delivery and broaden the range of its possible pharmaceutical applications. Halloysite was found to be a viable and inexpensive nanoscale container for the encapsulation of biological active molecules [4]. In this communication we report data about a new potential curcumin carrier based on positively charged functionalized halloysite nanotubes with triazolium salts (f-HNT). The interaction between curcumin and f-HNT was investigated by classical techniques as well as the release. Furthermore different cancer cell lines were used to evaluate the potential cytotoxic effect of the drug-carrier system.