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PATRIZIA DIANA

Synthesis of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one

  • Authors: Diana, P; Stagno, A; Barraja, P; Montalbano, A; Carbone, A; Parrino, B; Cirrincione G
  • Publication year: 2011
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: Pyrrolizino[2,3-b]indol-4(5H)-one Tripentone Antitumor activity Antitubulin agents
  • OA Link: http://hdl.handle.net/10447/55073

Abstract

Derivatives of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one were prepared in four steps starting from substituted benzonitriles bearing a functionalized amino group in the adjacent position. The unsubstituted- and the dimethoxy-pyrrolizinoindolones 5a and 5b exhibited modest activity against the HL-60(TB) human leukemia cell line, whereas the N-methylated dimethoxy-pyrrolizinoindolone 6b showed to be selective against MOLT-4 leukemia, A549/ATCC, HOP-92, and NCI-H460 non-small cell lung cancer, and CAKI-1 renal cancer cell lines.