Analysis of Ki-Ras mutations in stage I rectal carcinomas and respective regional lymph nodes.
- Autori: FIORENTINO FP; AGNESE V; CALÒ V; BRUNO L; AUGELLO C; CASCIO S; BARBERA F; GARGANO G; GREGORIO V; CALCARA D; LA PAGLIA L; SCHIRO V; TERRASI M; FANALE D; SCOLARO L; GRACEFFA G; DI GAUDIO F; BAZAN, V; RUSSO, A; Agnello, G.
- Anno di pubblicazione: 2007
- Tipologia: Proceedings
- OA Link: http://hdl.handle.net/10447/13306
Abstract
In this work we show that the percentage of Ki-RAS mutations in codons 12 and 13 in rectal cancer are sensibly lower than in colon cancer, providing further evidence that these two kinds of tumors should be considered two different entities. Moreover, we show that the detection in regional lymph nodes of the same mutation of primary tumor might represent an indicator of lymph nodes metastasis in rectal carcinoma not detected in routine histologic examination.