Immunological and immunogenetic markers in sporadic Alzheimer's disease
- Authors: LIO D; SCOLA L; COLONNA ROMANO G; CANDORE G; CARUSO C
- Publication year: 2006
- Type: Articolo in rivista (Articolo in rivista)
- Key words: Alzheimer’s disease, cytokines, immunogenetics, inflammation, proteomics
- OA Link: http://hdl.handle.net/10447/17627
Abstract
Background: Common polymorphisms of genes controlling inflammation-modulating cytokines and acute-phase proteins which play important roles in the pathogenesis of Alzheimer''s disease (AD) have been shown to be associated with AD. Aims: The immunological and immunogenetic markers potentially useful for the AD risk evaluation and diagnosis are briefly reviewed. Conclusion: The state-of-the-art of immunological and immunogenetic markers of AD indicates that new tools and strategies are necessary to identify gene products useful as diagnostic tools.