Gender-Related Differences in Presentation, Treatment, and Outcome of Patients With Atrial Fibrillation in Europe. A Report From the Euro Heart Survey on Atrial Fibrillation
- Autori: Dagres N.; Nieuwlaat R.; Vardas P.E.; Andresen D.; Levy S.; Cobbe S.; Kremastinos D.Th.; Breithardt G.; Cokkinos D.V.; Crijns H.J.G.M.; Camm A.J.; Davies W.; Capucci A.; Olsson B.; Aliot E.; Le Heuzey J.-Y.; Santini M.; Manini M.; Bramley C.; Laforest V.; Taylor C.; Del Gaiso S.; Huber K.; De Backer G.; Sirakova V.; Cerbak R.; Thayssen P.; Lehto S.; Blanc J.-J.; Delahaye F.; Kobulia B.; Zeymer U.; Karlocai K.; Graham I.; Shelley E.; Behar S.; Maggioni A.; Goncalves L.; Grabauskiene V.; Asmussen I.; Deckers J.; Stepinska J.; Mareev V.; Vasiljevic Z.; Riecansky I.; Kenda M.F.; Alonso A.; Lopez-Sendon J.L.; Rosengren A.; Buser P.; Okay T.; Sychov O.; Fox K.; Schofield P.; Simoons M.; Wood D.; Battler A.; Boersma E.; Fox K.; Komajda M.; McGregor K.; Mulder B.; Priori S.; Ryden L.; Vahanian A.; Wijns W.; Sanofi-Aventis; Grigoryan S.V.; Apetyan I.; Aroyan S.; Azarapetyan L.; Anvari A.; Gottsauner-Wolf M.; Pfaffenberger S.; Aydinkoc K.; Kalla K.; Penka M.; Drexel H.; Langer P.; Pierard L.A.; Legrand V.; Blommaert D.; Schroeder E.; Mancini I.; Geelen P.; Brugada P.; De Zutter M.; Vrints C.; Vercammen M.; Morissens M.; Borisov B.; Petrov V.A.; Marinova M.; Assen A.; Goudev R.; Peychev Y.; Stoyanovsky V.; Stoynev E.; Kranjcevic S.; Moutiris J.; Ioannides M.; Evequoz D.; Spacilova J.; Novak M.; Eisenberger M.; Mullerova J.; Kautzner J.; Riedlbauchova L.; Petru` J.; Taborsky M.; Cappelen H.; Sharaf Y.A.; Ibrahim B.S.S.; Tammam K.; Saad A.; Elghawaby H.; Sherif H.Z.; Farouk H.; Mielke A.; Engelen M.; Kirchhof P.; Zimmermann P.; Aviles F.F.; Rubio J.; Malpartida F.; Corona M.; Sanchez L.T.; Miguel J.; Herrera L.; Quesada A.; Garcia A.J.M.; Gonzalez C.S.; Juango M.S.A.; Berjon-Reyero J.; Alegret J.M.; Fernandez J.M.C.; Carrascosa C.; Romero R.A.F.; Lara M.G.; Sendon J.L.L.; de Diego J.J.G.; Martin L.S.; Irurita M.; Guttierez N.H.; Rubio J.R.S.; Antorrena I.; Paves A.B.; Salvador A.; Orriach M.D.; Garcia A.A.; Epelde F.; Martinez V.B.; Sanchez A.B.; Galvez C.P.; Rivero R.F.; Madrid A.H.; Baron-Esquivias G.; Peinado R.; Guindal J.A.G.; Vera T.R.; Fernandez E.L.; Gayan R.; Garcia J.; Bodegas A.; Lopez J.T.; Florez J.M.; Cabezas C.L.; de Castroviejo E.V.R.; Bellido J.M.; Ruiz M.E.; Savolainen K.; Nieminen M.; Toivonen L.; Syvanne M.; Pietila M.; Galley D.; Beltra C.; Gay A.; Daubert J.C.; Lecocq G.; Poulain C.; Cleland J.G.F.C.; Shelton R.; Choudhury A.; Abuladze G.; Jashi I.; Tsiavou A.; Giamouzis G.; Kostopoulou A.; Tsoutsanis D.; Stefanadis C.; Latsios G.; Vogiatzis I.; Gotsis A.; Bozia P.; Karakiriou M.; Koulouris S.; Parissis J.; Kostakis G.; Kouris N.; Kontogianni D.; Athanasios K.; Douras A.; Tsanakis T.; Marketou M.; Patsourakos N.; Czopf L.; Halmosi R.; Preda I.; Csoti E.; Badics A.; Strasberg B.; Freedberg N.A.; Katz A.; Zalzstein E.; Grosbard A.; Goldhammer E.; Nahir M.; Epstein M.; Vider I.; Luria D.; Mandelzweig L.; Aloisi B.; Cavallaro A.; Antonielli E.; Doronzo B.; Pancaldo D.; Mazzola C.; Buontempi L.; Calvi V.; Giuffrida G.; Figlia A.; Ippolito F.; Gelmini G.-P.; Gaibazzi N.; Ziacchi V.; De Tommasi F.; Lombardi F.; Fiorentini C.; Terranova P.; Maiolino P.; Albunni M.; Pinna-Pintor P.; Fumagalli S.; Masotti G.; Boncinelli L.; Rossi D.; Santoro G.M.; Fioranelli M.; Naccarella F.; Maranga S.S.; Lepera G.; Bresciani B.; Seragnoli E.; Forti M.C.; Cortina V.; Baciarello G.; Cicconetti P.; Lax A.; Vitali F.; Igidbashian D.; Scarpino L.; Terrazzino S.; Tavazzi L.; Cantu F.; Pentimalli F.; Novo S.; Coppola G.; Zingarini G.; Ambrozio G.; Moruzzi P.; Callegari S.; Saccomanno G.; Russo P.; Carbonieri E.; Paino A.; Zanetta M.; Barducci E.; Cemin R.; Rauhe W.; Pitscheider W.; Meloni M.; Marchi S.M.; Di Gennaro M.; Calcagno S.; Squaratti P.; Quartili F.; Bertocchi P.; De Martini M.; Mantovani G.; Komorovsky R.; Desideri A.; Celegon L.; Tarantini L.; Catania G.; Lucci D.; Bianchini F.; Puodziukynas A.; Kavoliuniene A.; Barauskiene V.; Aidietis A.; Barysiene J.; Vysniauskas V.; Zukauskiene I.; Kazakeviciene N.; Georgievska-Ismail L.; Poposka L.;
- Anno di pubblicazione: 2007
- Tipologia: Articolo in rivista
- Parole Chiave: Aged; Aged, 80 and over; Atrial Fibrillation; Europe; Female; Follow-Up Studies; Health Status; Health Surveys; Heart Failure; Humans; Male; Middle Aged; Quality of Life; Stroke; Treatment Outcome; Sex Factors
- OA Link: http://hdl.handle.net/10447/365118
Abstract
Objectives: This study sought to investigate gender-related differences in patients with atrial fibrillation (AF) in Europe. Background: Gender-related differences may play a significant role in AF. Methods: We analyzed the data of 5,333 patients (42% female) enrolled in the Euro Heart Survey on Atrial Fibrillation. Results: Compared with men, the women were older, had a lower quality of life (QoL), had more comorbidities, more often had heart failure (HF) with preserved left ventricular systolic function (18% vs. 7%, p < 0.001), and less often had HF with systolic dysfunction (17% vs. 26%, p < 0.001). Among patients with typical AF symptoms (56% of women, 49% of men), there was no gender-related difference in the choice of rate or rhythm control. Among patients with atypical or no symptoms (44% of women, 51% of men), women less frequently underwent rhythm control (39% vs. 51%, p < 0.001) than did men. Women underwent less electrical cardioversion (22% vs. 28%, p < 0.001). Prescription of oral anticoagulants was identical (65%) in both genders. One-year outcome was similar except that women had a higher chance for stroke (odds ratio 1.83 in multivariable regression analysis, p = 0.019). Conclusions: Women with AF had more comorbidities, more HF with preserved systolic function, and a lower QoL than men. In the large group with atypical or no symptoms, women were treated appropriately more conservatively with less rhythm control than men. Women had a higher chance for stroke. Long-term QoL changes and other morbidities and mortality were similar. © 2007 American College of Cardiology Foundation.