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GIROLAMO CASELLA

Organotin(IV)derivatives neurotoxicity and their modulation by Baclofen

  • Authors: PRINZIVALLI C; ABBATE M; CASELLA G; CATALDO S; FIORE T; NAGY L; PELLERITO C; SCOPELLITI M; PELLERITO L
  • Publication year: 2008
  • Type: Articolo in rivista (Articolo in rivista)
  • Key words: Organotin(IV), Baclofen, Mossbauer, FT-IR, NMR
  • OA Link: http://hdl.handle.net/10447/35104

Abstract

Several new diorganotin(IV) and triorganotin(IV) complexes with 4-amino-3- (4-chloro phenyl)]-butanoic acid ( = Baclofen) have been synthesized and their structure investigated both in the solid state and in solution phase through spectroscopic methods (FT-IR, Mössbauer, 1H and 13C NMR). According to experimental analytical data, the stoichiometry of the complexes has been proposed as R2SnBac2 and R3SnBac, respectively for diorganotin(IV) and triorganotin(IV) baclofen complexes. (Baclofen = HBac; R = Me, Bu, Ph).