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FABIO CARADONNA

A new pericentric inv(8) in acute nonlymphocytic leukemia

  • Authors: Santoro, A; Carbone, P; Caradonna, F; Fabbiano, F; Mirto, S; Caronia, F
  • Publication year: 1993
  • Type: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/599276

Abstract

Chromosome studies were carried out on unstimulated bone marrow cells from a patient with a diagnosis of acute nonlymphocytic leukemia (FAB M6 ANLL). Cytogenetic analysis revealed a mosaic chromosome pattern 46,XX/46,XX, inv(8)(p21q24). This pericentric inversion has not been previously described in ANLL. Because, fragile sites, zinc finger gene loci, and the MYC protooncogene have been localized to band 8q24, a putative role for these sites and genes could be considered.