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FABIO CARADONNA

Effect of gene-gene and gene-environment interactions associated with antituberculosis drug-induced hepatotoxicity

  • Authors: Chamorro, J.; Castagnino, J.; Aidar, O.; Musella, R.; Frías, A.; Visca, M.; Nogueras, M.; Costa, L.; Perez, A.; Caradonna, F.; de Larrañaga, G.
  • Publication year: 2017
  • Type: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/241587

Abstract

This study evaluated the association between environmental factors and genetic variations in enzymes that metabolize antituberculosis (anti-TB) drugs [arylamine N-acetyltransferase 2, cytochrome P450 2E1 (CYP2E1), glutathione S-transferase theta 1 (GSTT1), and glutathione S-transferase mu 1] with antituberculosis drug-induced hepatotoxicity (ATDH). We also investigated the potential gene-gene and gene-environment interactions as well as their association with ATDH development in a population of hospitalized TB patients from Buenos Aires.